Oligomycin A A mitochondrial ATPase inhibitor
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Oligomycin A (CAS 579-13-5)

Oligomycin A | CAS 579-13-5 is rated 5.0 out of 5 by 1.
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See product citations (7)
Application: A mitochondrial ATPase inhibitor
CAS Number: 579-13-5
Purity: >95%
Molecular Weight: 791.06
Molecular Formula: C45H74O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.


References

1. Linnett, P.E., et al. 1979. Meth. Enzymol. 55: 472-518. PMID: 156854
2. Van Dyke, R.W. 1993. Am. J. Physiol. 265: C901-C917. PMID: 8238315
3. Fitch, M.E., et al. 2000. Cell Death Differ. 7: 338-349. PMID: 10773818
4. Peachman, K.K., et al. 2001. Proc. Natl. Acad. Sci. U.S.A. 98: 1717-1722. PMID: 11172017
5. Zhang, X., et al. 2006. Cell Res. 16: 841-850. PMID: 16983401

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO (300 mg/ml), ethanol (200 mg/ml), acetone (800 mg/ml), glacial acetic acid (37.5 g/100ml) at 25° C, water (2 mg/100ml) at 25° C, ether (28 g/100ml) at 25° C, and benzene (6 g/100ml) at 25° C.
Storage :
Store at -20° C
Boiling Point :
886.3° C at 760 mmHg (Predicted)
Density :
1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RK3328000
PubChem CID :
6364620
Merck Index :
14: 6833
MDL Number :
MFCD00065705
EC Number :
209-437-3
Beilstein Registry :
5702132
SMILES :
CCC\1CCC2[C@@H](C([C@H](C3(O2)CC[C@H](C(O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@@H]([C@H]([C@@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C

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Certificate of Analysis

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Oligomycin A  Product Citations

See how others have used Oligomycin A. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 28923859  Phillips, CM. et al. 2017. Cancer Res. 77: 5741-5754.

PMID: # 26566717  Sin, J. et al. 2016. Autophagy. 12: 369-80.

PMID: # 25986861  Chang, SH. et al. 2015. Biochim. Biophys. Acta. 1853: 2306-25.

PMID: # 25511868  Serrill, JD. et al. 2015. Biochem. Pharmacol. 93: 251-65.

PMID: # 25483094  Xavier, JM. et al. 2014. Cell Cycle. 13: 3576-89.

PMID: # 22987451  Porceddu, M. et al. 2012. Toxicol. Sci. 129: 332-45.

PMID: # 21248260  Andris, F. et al. 2011. J. Immunol. 186: 2245-2253.

Citations 1 to 7 of 7 total

What is the purity?

Asked by: SCM4
This chemical, Oligomycin A (CAS 579-13-5), has a purity of >95%.
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Andris Andris, F. et al. (PubMed 21248260) found that Oligomycin A, an inhibitor of mitochondrial ATPases, enhances antibody production when coinjected with T cell-dependent antigens. Oligomycin A lead to intracellular ATP reduction, suggesting that metabolic stress could be sensed by immune cells and leads to increased humoral responses. -SCBT Publication Review
Date published: 2015-01-06
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