Oligomycin A A mitochondrial ATPase inhibitor

Oligomycin A (CAS 579-13-5)

Oligomycin A | CAS 579-13-5 is rated 5.0 out of 5 by 1.
  • y_2019, m_7, d_18, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201551, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 85ms
  • REVIEWS, PRODUCT
Datasheets
Application: A mitochondrial ATPase inhibitor
CAS Number: 579-13-5
Purity: >95%
Molecular Weight: 791.06
Molecular Formula: C45H74O11
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.


References

1. Linnett, P.E., et al. 1979. Meth. Enzymol. 55: 472-518. PMID: 156854
2. Van Dyke, R.W. 1993. Am. J. Physiol. 265: C901-C917. PMID: 8238315
3. Fitch, M.E., et al. 2000. Cell Death Differ. 7: 338-349. PMID: 10773818
4. Peachman, K.K., et al. 2001. Proc. Natl. Acad. Sci. U.S.A. 98: 1717-1722. PMID: 11172017
5. Zhang, X., et al. 2006. Cell Res. 16: 841-850. PMID: 16983401

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO (300 mg/ml), ethanol (200 mg/ml), acetone (800 mg/ml), glacial acetic acid (37.5 g/100ml) at 25° C, water (2 mg/100ml) at 25° C, ether (28 g/100ml) at 25° C, and benzene (6 g/100ml) at 25° C.
Storage :
Store at -20° C
Boiling Point :
886.3° C at 760 mmHg (Predicted)
Density :
1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RK3328000
PubChem CID :
6364620
Merck Index :
14: 6833
MDL Number :
MFCD00065705
EC Number :
209-437-3
Beilstein Registry :
5702132
SMILES :
CCC\\1CCC2[C@@H](C([C@H](C3(O2)CC[C@H](C(O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@@H]([C@H]([C@@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Oligomycin A  Product Citations

See how others have used Oligomycin A. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 28923859  Phillips, CM. et al. 2017. Cancer Res. 77: 5741-5754.

PMID: # 26566717  Sin, J. et al. 2016. Autophagy. 12: 369-80.

PMID: # 25986861  Chang, SH. et al. 2015. Biochim. Biophys. Acta. 1853: 2306-25.

PMID: # 25511868  Serrill, JD. et al. 2015. Biochem. Pharmacol. 93: 251-65.

PMID: # 25483094  Xavier, JM. et al. 2014. Cell Cycle. 13: 3576-89.

PMID: # 22987451  Porceddu, M. et al. 2012. Toxicol. Sci. 129: 332-45.

PMID: # 21248260  Andris, F. et al. 2011. J. Immunol. 186: 2245-2253.

Citations 1 to 7 of 7 total

What is the purity?

Asked by: SCM4
This chemical, Oligomycin A (CAS 579-13-5), has a purity of >95%.
Answered by: Chemical Support 1
Date published: 2017-03-24
  • y_2019, m_7, d_18, h_21CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_201551, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 82ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Andris Andris, F. et al. (PubMed 21248260) found that Oligomycin A, an inhibitor of mitochondrial ATPases, enhances antibody production when coinjected with T cell-dependent antigens. Oligomycin A lead to intracellular ATP reduction, suggesting that metabolic stress could be sensed by immune cells and leads to increased humoral responses. -SCBT Publication Review
Date published: 2015-01-06
  • y_2019, m_7, d_18, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201551, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 30ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.