Okadaic Acid, Ammonium Salt A protein phosphatase regulator

Okadaic Acid, Ammonium Salt (CAS 155716-06-6)

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Application: A protein phosphatase regulator
CAS Number: 155716-06-6
Purity: ≥98%
Molecular Weight: 822.0
Molecular Formula: C44H67O13•NH4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Okadaic Acid, Ammonium Salt, a toxin originally derived from Halichondria okadai, has been reported to have a relatively high specificity for PP1, PP2A, and polycation-modulated phosphatases. The mechanistic studies show that this is achieved by the compound's non-competitive or mixed inhibition of the okadaic acid-sensitive enzymes. Additional experiments have noted Okadaic Acid to induce ornithine decarboxylase in mouse skin and be a non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter in murine skin carcinogenesis. Okadaic Acid displays the capacity to inhibit insulin secretion induced by ketoisocaproate, high K+, and Tolbutamide (sc-203298), via suppression of the magnitude of Ca2+ signal in β cells. Okadaic Acid, Ammonium Salt is an activator of PKC ζ, PKC ι and PKC λ. Okadaic Acid, Ammonium Salt is an inhibitor of PP1 and PP2A.


References

1. Bialojan, C. and Takai, A. 1988. Biochem. J. 256: 283-290. PMID: 2851982
2. Suganuma, M., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 1768-1771. PMID: 3126494
3. Gjertsen, B.T., et al. 1994. J. Cell. Sci. 107: 3363-3377. PMID: 7706392
4. Easom, R.A., et al. 1998. Biochem. J. 329: 283-288. PMID: 9425110
5. Sato, Y., et al. 1998. Br. J. Pharmacol. 123: 97-105. PMID: 9484859

Physical State :
Solid
Solubility :
Soluble in DMSO, 100% ethanol, methanol, acetone, ethyl acetate, and water (0.1 mg/mL).
Storage :
Store at -20° C
Melting Point :
50-70° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219809
MDL Number :
MFCD00153856
SMILES :
C[C@@H]1CC[C@]2(CCCCO2)OC1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4C(O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)[O-])O)O)C)O)O.[NH4+]

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Certificate of Analysis

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Okadaic Acid, Ammonium Salt  Product Citations

See how others have used Okadaic Acid, Ammonium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 10215588  Wilson, NJ. et al. 1999. Biochem. J. 339 ( Pt 3): 517-524.

PMID: # 9882497  Cobb, J. et al. 1999. Dev. Biol. 205: 49-64.

PMID: # 9973408  Manna, SK. et al. 1999. J. Immunol. 162: 1510-1518.

PMID: # 9721183  Dignam, SS. et al. 1998. Arch. Biochem. Biophys. 357: 58-66.

PMID: # 9484859  Sato, Y. et al. 1998. Br. J. Pharmacol. 123: 97-105.

PMID: # 9425110  Easom, RA. et al. 1998. Biochem. J. 329 ( Pt 2): 283-288.

PMID: # 8921009  Guo, YL. et al. 1996. Biochem. J. 319 ( Pt 3): 985-991.

PMID: # 7706392  Gjertsen, BT. et al. 1994. J. Cell. Sci. 107 ( Pt 12): 3363-3377.

PMID: # 3126494  Suganuma, M. et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 1768-1771.

PMID: # 2851982  Bialojan, C. et al. 1988. Biochem. J. 256: 283-290.

Citations 1 to 10 of 10 total
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