Okadaic Acid, Ammonium Salt, a toxin originally derived from Halichondria okadai, has been reported to have a relatively high specificity for PP1, PP2A, and polycation-modulated phosphatases. The mechanistic studies show that this is achieved by the compound's non-competitive or mixed inhibition of the okadaic acid-sensitive enzymes. Additional experiments have noted Okadaic Acid to induce ornithine decarboxylase in mouse skin and be a non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter in murine skin carcinogenesis. Okadaic Acid displays the capacity to inhibit insulin secretion induced by ketoisocaproate, high K+, and Tolbutamide (sc-203298), via suppression of the magnitude of Ca2+ signal in β cells. Okadaic Acid, Ammonium Salt is an activator of PKC ζ, PKC ι and PKC λ. Okadaic Acid, Ammonium Salt is an inhibitor of PP1 and PP2A.
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See how others have used Okadaic Acid, Ammonium Salt. Click on the entry to view the PubMed entry .
PMID: # 10215588 Wilson, NJ. et al. 1999. Biochem. J. 339 ( Pt 3): 517-524.
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PMID: # 9721183 Dignam, SS. et al. 1998. Arch. Biochem. Biophys. 357: 58-66.
PMID: # 9484859 Sato, Y. et al. 1998. Br. J. Pharmacol. 123: 97-105.
PMID: # 9425110 Easom, RA. et al. 1998. Biochem. J. 329 ( Pt 2): 283-288.
PMID: # 8921009 Guo, YL. et al. 1996. Biochem. J. 319 ( Pt 3): 985-991.
PMID: # 7706392 Gjertsen, BT. et al. 1994. J. Cell. Sci. 107 ( Pt 12): 3363-3377.
PMID: # 3126494 Suganuma, M. et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 1768-1771.
PMID: # 2851982 Bialojan, C. et al. 1988. Biochem. J. 256: 283-290.
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