Octylonium Bromide Octylonium Bromide has been reported to antagonize PAF induced aggregation of rabbit platelet-rich plasma. It demonstrates the ability to potently block neuronal nicotinic acetylcholine receptors.

Octylonium Bromide  (CAS 26095-59-0)

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Application: A PAF-R inhibitor
CAS Number: 26095-59-0
Purity: 98%
Molecular Weight: 563.6
Molecular Formula: C29H43N2O4Br
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Octylonium Bromide sc-201035 5 mg $154.00
Octylonium Bromide sc-201035A 25 mg $583.00

Octylonium Bromide has been reported to antagonize PAF (platelet-activating factor) induced aggregation of rabbit platelet-rich plasma, hypotension in rats, lethality in mice, and bronchoconstriction in guinea-pigs. This compound also demonstrates the ability to potently block neuronal nicotinic acetylcholine receptors and also a mild wide-spectrum Ca2+ channel blocker in bovine adrenal chromaffin cells. Additionally, Octylonium Bromide has been shown to inhibit muscular action potentials carried by L-type Ca2+ current. Octylonium Bromide is an inhibitor of PAF-R.


References

1. Subissi, A., et al. 1989. Arch Int Pharmacodyn Ther. 302: 255-267. PMID: 2636821
2. Gandía, L., et al. 1996. Br. J. Pharmacol. 117: 463-470. PMID: 8821535
3. Martin, M.T., et al. 2004. Neurogastroenterol. Motil. 16: 175-183. PMID: 15086871

Physical State :
Solid
Solubility :
Soluble in water (12 mg/mL), DMSO (>25 mg/mL), ethanol (>25 mg/mL), and methanol.
Storage :
Store at -20° C
Melting Point :
166-168° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
BP7610000
PubChem CID :
72092
EC Number :
247-457-4
SMILES :
[Br-].CCCCCCCCOC1=CC=CC=C1C(=O)NC1=CC=C(C=C1)C(=O)OCC[N+](C)(CC)CC

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Certificate of Analysis

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Citations 1 to 3 of 3 total

PMID: # 15086870
Strege, PR. et al. 2004. Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle. Neurogastroenterol. Motil.. 16: 167-173.

PMID: # 9798806
Battaglia, G. et al. 1998. Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment. Pharmacol. Ther.. 12: 1003-1010.

PMID: # 3168757
Manzini, S. et al. 1988. Further studies on the pharmacodynamic properties and organ selectivity of octylonium bromide. Drugs Exp Clin Res. 14: 265-270.

Citations 1 to 3 of 3 total
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