Octylonium Bromide has been reported to antagonize PAF (platelet-activating factor) induced aggregation of rabbit platelet-rich plasma, hypotension in rats, lethality in mice, and bronchoconstriction in guinea-pigs. This compound also demonstrates the ability to potently block neuronal nicotinic acetylcholine receptors and also a mild wide-spectrum Ca2+ channel blocker in bovine adrenal chromaffin cells. Additionally, Octylonium Bromide has been shown to inhibit muscular action potentials carried by L-type Ca2+ current. Octylonium Bromide is an inhibitor of PAF-R.
1. Subissi, A., et al. 1989. Arch Int Pharmacodyn Ther. 302: 255-267. PMID: 2636821
2. Gandía, L., et al. 1996. Br. J. Pharmacol. 117: 463-470. PMID: 8821535
3. Martin, M.T., et al. 2004. Neurogastroenterol. Motil. 16: 175-183. PMID: 15086871
See how others have used Octylonium Bromide. Click on the entry to view the PubMed entry .
PMID: # 15086870
Strege, PR. et al. 2004. Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle. Neurogastroenterol. Motil.. 16: 167-173.
PMID: # 9798806
Battaglia, G. et al. 1998. Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment. Pharmacol. Ther.. 12: 1003-1010.
PMID: # 3168757
Manzini, S. et al. 1988. Further studies on the pharmacodynamic properties and organ selectivity of octylonium bromide. Drugs Exp Clin Res. 14: 265-270.
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