OAC-1 An Oct-4 activator which increases mRNA expression of Oct-4, Sox-2, Nanog, and Tet1

OAC-1 (CAS 300586-90-7)

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Synonym: N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide
Application: An Oct-4 activator which increases mRNA expression of Oct-4, Sox-2, Nanog, and Tet1
CAS Number: 300586-90-7
Molecular Weight: 237.26
Molecular Formula: C14H11N3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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OAC-1 is an Oct-4 activator which enhances and accelerates iPSC reprogramming in the presence of 4F (Oct-4, Sox-2, c-Myc and GKLF) by ~20-fold (relative to 4F by itself). OAC-1 upregulates mRNA expression of Oct-4, Sox-2 and Nanog, as well as Tet1. It has shown no effects, however, on the p53-p21 pathway or Wnt-β-catenin signaling.


References

1. Li, Wendong., et al., 2012. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proceedings of the National Academy of Sciences of the United States of America. 109(51): 20853-8. PMID: 23213213

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
197.05° C (Predicted)
Boiling Point :
~386.6° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
789882
SMILES :
C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3

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Certificate of Analysis

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