O-Phospho-L-serine A competitive NMDA antagonist/ group III mGluR agonist

O-Phospho-L-serine (CAS 407-41-0)

O-Phospho-L-serine | CAS 407-41-0 is rated 5.0 out of 5 by 1.
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Synonym: L-2-Amino-3-hydroxypropanoic acid 3-phosphate
Application: A competitive NMDA antagonist/ group III mGluR agonist
CAS Number: 407-41-0
Purity: ≥97%
Molecular Weight: 185.07
Molecular Formula: C3H8NO6P
* Refer to Certificate of Analysis for lot specific data (including water content).
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O-Phospho-L-serine is an L-AP4 (sc-200432) agonist and a competitive NMDA antagonist. O-Phospho-L-serine has affinity for mGluR-4 (type IV), but not type I, metabotropic glutamate group III receptor agonist (mGluR-4, mGluR-7, and mGluR-8). O-Phospho-L-serine also inhibits proliferation and enhances neuronal differentiation in progenitor cells.


References

1. Klunk, W E., et al., 1991. L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes. Journal of neurochemistry. 56(6): 1997-2003. PMID: 1673996
2. Thomsen, C., et al., 1993. Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 4(9): 1099-101. PMID: 8106006
3. Borodezt, K., et al., 1998. Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis. Journal of neuroscience research. 53(5): 531-41. PMID: 9726424

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at 4° C
Melting Point :
190° C
Boiling Point :
~475.36° C at 760 mmHg (Predicted)
Density :
~1.81 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Optical Activity :
α25/D 16.05°±0.65°, c = 1 in 2 M HCl; α20/D +5°±1°, c = 2 in water
IC50 :
mGluR-4: EC5050 = 1 µM (human); Plasmodium falciparum: EC5050 >1.07 µM; mGluR-6: EC5050 = 2.7 µM (rat); PSM: IC50 = 523 µM (human)
pK Values :
pKa: 1.71 (Predicted), pKb: 11.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
68841
Merck Index :
14: 7363
MDL Number :
MFCD00065935
EC Number :
206-986-0
Beilstein Registry :
1726826
SMILES :
C(C(C(=O)O)N)OP(=O)(O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Gaitonde P; et al Gaitonde P; et al. (PubMed ID: 25459532) determined that O-Phospho-L-serine increased the secretion of immunosuppressive cytokines and decreased pro-inflammatory IL-17 cytokine. -SCBT Publication Review
Date published: 2015-05-31
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