O-Phospho-L-serine is an L-AP4 (sc-200432) agonist and a competitive NMDA antagonist. O-Phospho-L-serine has affinity for mGluR-4 (type IV), but not type I, metabotropic glutamate group III receptor agonist (mGluR-4, mGluR-7, and mGluR-8). O-Phospho-L-serine also inhibits proliferation and enhances neuronal differentiation in progenitor cells.
1. Klunk, W E., et al., 1991. L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes. Journal of neurochemistry. 56(6): 1997-2003. PMID: 1673996 2. Thomsen, C., et al., 1993. Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 4(9): 1099-101. PMID: 8106006 3. Borodezt, K., et al., 1998. Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis. Journal of neuroscience research. 53(5): 531-41. PMID: 9726424
Soluble in water (50 mg/ml).
Store at 4° C
~475.36° C at 760 mmHg (Predicted)
~1.81 g/cm3 (Predicted)
n20D 1.55 (Predicted)
α25/D 16.05°±0.65°, c = 1 in 2 M HCl; α20/D +5°±1°, c = 2 in water
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Gaitonde P; et alGaitonde P; et al. (PubMed ID: 25459532) determined that O-Phospho-L-serine increased the secretion of immunosuppressive cytokines and decreased pro-inflammatory IL-17 cytokine. -SCBT Publication Review
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