O-deacetylravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light dependent antitumour activity. O-Deacetylravidomycin is an inhibitor of Topo II. Microbial Screening Technologies in-house bioassays detected weak antibacterial and antifungal activity.
1. New ravidomycin analogues, FE35A and FE35B, apoptosis inducers produced by Streptomyces rochei. Yamashita N. et al. J. Antibiot. 1998, 51, 1105. 2. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer 1993, 29A, 1985. 3. Light-dependent activity of the antitumor antibiotics ravidomycin and desacetylravidomycin. Greenstein M. et al. Antimicrob. Agents Chemother. 1986, 29, 861. 4. Chemical modification of ravidomycin and evaluation of biological activities of its derivatives. Rakhit S. et al. Antimicrob. Agents Chemother. 1986, 29, 861.
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