Nystatin A polyene antifungal and antibiotic which increases membrane permeability

Nystatin (CAS 1400-61-9)

Nystatin | CAS 1400-61-9 is rated 5.0 out of 5 by 1.
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Synonym: Fungicidin; Mycostatin
Application: A polyene antifungal and antibiotic which increases membrane permeability
CAS Number: 1400-61-9
Molecular Weight: 926.09
Molecular Formula: C47H75NO17
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nystatin is a polyene antifungal, antibiotic complex containing three biologically active components: A1, A2, and A3. It increases the permeability of the cell membrane of sensitive fungi by binding to sterols. It is a growth promoter.


References

Brautaset, T., et al.: Chem. Biol., 7, 395 (2000), Brautaset, T., et al.: J. Biol. Chem., 278, 14913 (2003), Bruheim, P., et al.: Antimicrob. Agents Chemother., 48, 4120 (2004), Scott, L., et al.: Drugs, 67, 269 (2007),

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5311331
SMILES :
C[C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)OC\\2CC3C(C(CC(O3)(CC(C(CCC(CC(CC(CC(=O)OC(C(C(C(/C=C/C=C/CC/C=C/C=C/C=C/C=C2)C)O)C)C)O)O)O)O)O)O)O)C(=O)O)O)N)O

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Certificate of Analysis

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I bought 5 MU (sc-212431) but no description about what gram of nystatin is contained in the glass tube. In your description "DMF is the recommended solvent to use with a working concentration of 50mg/L", what is the unit of the 50mg?

Asked by: Yukinobu
Thank you for your question. Here is a link to a recent CoA. http://datasheets.scbt.com/coa/coa.php?sc=sc-212431&lot=A3017
Answered by: Tech Service
Date published: 2019-02-14

What is the definition of unit of nystatin? WHich is the reference?

Asked by: Yukinobu
Thank you for your question. DMF is the recommended solvent to use with a working concentration is 50mg/L. The potency is ≥5000 u/mg.
Answered by: Tech Service
Date published: 2019-02-15

What is the concentrration of unit to use in cell culture to prevent fungi growth?

Asked by: Yukinobu
Thank you for your question. DMF is the recommended solvent to use with a working concentration of 50mg/L.
Answered by: Technical Support
Date published: 2019-02-14

Qual é o percentual de pureza desse produto?

Asked by: DANY31
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2016-11-07
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Rated 5 out of 5 by from Ginovyan et al Ginovyan et al. (PubMed ID 25982441) used Nystatin, a polyene anti-fungal, as a control agent for comparative analysis of bacteriostatic activity in a variety of microorganisms. -SCBT Publication Review
Date published: 2015-04-20
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