NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (nucleolar phosphoprotein B23). NSC 348884 inhibits NPM oligomer formation, up-regulates p53 and induces apoptosis.
Qi, W., et al., NSC34884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene, 1-11, (2008)
Soluble in DMSO (>20 mg/mL).
Store at 4° C
n20D ~1.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Zhang J; et alZhang J; et al. (PubMed ID: 22737721) determined that NSC348884 encourages the transformation of nucleophosmin oligomer to a monomer and thus inhibits the proliferation of HepG2 cells in vitro. -SCBT Publication Review
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