NSC348884 A biochemical which inhibitss NPM oligomer formation, upregulates p53 and induces apoptosis

NSC348884 (CAS 81624-55-7)

NSC348884 | CAS 81624-55-7 is rated 5.0 out of 5 by 1.
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Synonym: N,N,N',N' - tetrakis[(6 - methyl - 1H - benzimidazol - 2 - yl)methyl]ethane - 1,2 - diamine
Application: A biochemical which inhibitss NPM oligomer formation, upregulates p53 and induces apoptosis
CAS Number: 81624-55-7
Purity: ≥98%
Molecular Weight: 636.79
Molecular Formula: C38H40N10
* Refer to Certificate of Analysis for lot specific data (including water content).
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NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (nucleolar phosphoprotein B23). NSC 348884 inhibits NPM oligomer formation, up-regulates p53 and induces apoptosis.


References

Qi, W., et al., NSC34884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. Oncogene, 1-11, (2008)

Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/mL).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
335974
MDL Number :
MFCD12912428
SMILES :
CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Zhang J; et al Zhang J; et al. (PubMed ID: 22737721) determined that NSC348884 encourages the transformation of nucleophosmin oligomer to a monomer and thus inhibits the proliferation of HepG2 cells in vitro. -SCBT Publication Review
Date published: 2015-02-27
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