NS3694 A suppressor of the formation of apoptosome Apaf-1

NS3694 (CAS 426834-38-0)

NS3694 | CAS 426834-38-0 is rated 5.0 out of 5 by 1.
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Synonym: 4-Chloro-2-[3-(3-trifluoromethyl-phenyl)-ureido]benzoic acid; Apoptosis Inhibitor II
Application: A suppressor of the formation of apoptosome Apaf-1
CAS Number: 426834-38-0
Purity: ≥95%
Molecular Weight: 358.70
Molecular Formula: C15H10ClF3N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Apoptosis Inhibitor II, NS3694 is a cell-permeable diarylurea compound that suppresses the formation of the apoptosome Apaf-1. Studies suggest that the main component to signal the activation of apoptosis is the release of mitochondrial proapoptotic proteins into the cytosol which leads to the activation of caspases which form the apoptosome. Apoptosis Inhibitor II, NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. However, NS3694 does not exhibit any effect on apoptosome-independent caspase activation and enzymatic activity of caspases.


References

1. Lademann, U., et al. 2003. Mol. Cell. Biol. 23: 7829-7837. PMID: 14560026
2. Zhao, C.Q., et al. 2010. Age. 32: 161-177. PMID: 19960285

Physical State :
Solid
Solubility :
Soluble in DMSO (22 mg/ml), and ethanol (slightly soluble). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
204.67° C (Predicted)
Boiling Point :
~378.4° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
TNF-α-induced death: IC50 = 50 µM (MCF-casp3 cells); Glutamate receptor ionotropic kainate 1: IC50 = 5 µM (human)
pK Values :
pKa: 3.32 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10109069
MDL Number :
MFCD00249000
SMILES :
C1=CC(=CC(=C1)NC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)C(F)(F)F

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Certificate of Analysis

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Rated 5 out of 5 by from Shim G; et al Shim G; et al. (PubMed ID: 23747743) determined that NS3694 enhanced survival of transplanted adipose-derived stem cells in rabbits. -SCBT Publication Review
Date published: 2015-03-18
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