Nigericin sodium salt, a polyether antibiotic K+ and Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential and stimulates ATPase activity leading to rapid intracellular acidification resulting in apoptosis. Nigericin•Na has shown a role for inducing caspase-1-independent necrotic cell death. Nigericin•Na has also been found to increase membrane potential accelerating the rate of superoxide generation approaching the rate obtained by antimycin. Nigericin•Na is an activator of Cryopyrin.
1. Vercesi, A.E., et al. 1993. J. Biol. Chem. 268: 8564-8568. PMID: 8473301 2. Furlong, I.J., et al. 1997. J. Cell Sci. 110: 653-661. PMID: 9092947 3. Sze, H. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 5904-5908. PMID: 16592894 4. Hentze, H., et al. 2003. Cell Death Differ. 10: 956-968. PMID: 12934070 5. Rottenberg, H., et al. 2009. J. Biol. Chem. 284: 19203-19210. PMID: 19478336 6. Sze, H. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 5904-5908. PMID: 16592894
Soluble in DMSO (50 mg/ml), ethanol (20 mg/ml), dichloromethane (10 mg/ml), alcohols, acetone, ethyl acetate, chloroform, benzene, ether, DMF (1.2 mg/ml), and 1:5 ethanol:PBS (pH7.2) (0.15 mg/ml). Insoluble in water.
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This product is soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), dichloromethane (10 mg/ml), and methanol (10 mg/ml).
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Rottenberg et alRottenberg et al. (PubMed ID 19478336) used Nigericin sodium salt to increase mitochondrial membrane potential and accelerate the rate of superoxide generation by catalyzing the exchange of potassium and hydrogen ions. -SCBT Publication Review
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