Neurokinin A is a member of the endogenous tachykinin agonist with preference for the NK-2R (NK-2 receptor) with greater potency as a bronchoconstrictor than Substance P (sc-201169). The comound has shown to be identical to substance K and neuromedin L1. Neurokinin A has been reported to effect reproduction by controlling at the hypothalamus level gonadotropin and prolactin secretion along with steroid secretion at the ovarian and gonadal level. An increase in inositol 1,4,5-trisphosphate (IP3) levels along with paralleled increase in intracellular free Ca2+ in BHK-21 cells with the NK-2R gene were stimulated with Neurokinin A. The compound has also been observed to induce contraction in muscle strips and single cells of the human sigmoid colon circular muscle. Neurokinin A has also been used to discover the location of tachykinin receptors.
1. Eistetter, H.R., et al. 1993. J. Cell. Biochem. 52: 84-91. PMID: 8391539 2. Debeljuk, L. and Lasaga, M. 1999. Peptides. 20: 285-299. PMID: 10422885 3. Cao, W., et al. 2000. Gastroenterology. 119: 51-61. PMID: 10889154
Soluble in water (1 g/l) at 20° C, 10% acetonitrile / water (1 mg/ml), and 5% Acetic Acid.
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Cao et alCao et al. (PubMed ID 10889154) found that neurokinin A activated Gq-linked NK(2) receptors, inducing contraction and increase in cytosolic Ca(2+) in human sigmoid circular smooth muscle. -SCBT Publication Review
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