Neobavaisoflavone A DNA polymerase inhibitor and platelet aggregation inhibitor

Neobavaisoflavone (CAS 41060-15-5)

Neobavaisoflavone | CAS 41060-15-5 is rated 5.0 out of 5 by 1.
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Synonym: 7-Hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-chromen-4-one
Application: A DNA polymerase inhibitor and platelet aggregation inhibitor
CAS Number: 41060-15-5
Purity: ≥97%
Molecular Weight: 322.35
Molecular Formula: C20H18O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Neobavaisoflavone, an isoflavanone derivative, has been reported to display an anti-fungal capacity in vitro. Studies show that this compound can also capable of inhibiting platelet aggregation in rabbit platelets induced by arachidonic acid in vitro. Additional experiments have noted Neobavaisoflavone to be a DNA polymerase inhibitor and an enhancer of TRIAL-induced apoptosis of cells. TRIAL (tumor necrosis factor-related apoptosis-inducing ligand) is an agent that selectively induces programmed cell death in certain cells.


References

1. Nkengfack, A.E., et al. 1994. Phytochemistry. 36: 1047-1051. PMID: 7765206
2. Tsai, W.J., et al. 1996. J. Nat. Prod. 59: 671-672. PMID: 8759164
3. Sun, N.J., et al. 1998. J. Nat. Prod. 61: 362-366. PMID: 9544566
4. Bronikowska, J., et al. 2010. Molecules. 15: 2000-2015. PMID: 20336028

Physical State :
Solid
Derived From :
plant Psoralea corylifolia
Solubility :
Soluble in DMSO, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
206.97° C (Predicted)
Boiling Point :
545.01° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Platelet-activating factor-induced platelet aggregation : IC50 = 2.5 µM; Arachidonic acid-induced platelet aggregation preincubated : IC50 = 7.8 µM; Melanin synthesis : IC50 = 9.4 µM; Collagen-induced platelet aggregation: IC50 = 62.4 µM
pK Values :
pKa: 6.92 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5320053
MDL Number :
MFCD00800660
SMILES :
CC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Bronikowska et al Bronikowska et al. (PubMed ID 20336028) found that neobavaisoflavone induced apoptosis in HeLa cells by enhancing TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) cytotoxicity against cancer cells . -SCBT Publication Review
Date published: 2015-07-16
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