Necrostatin-5 An inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase.

Necrostatin-5  (CAS 337349-54-9)

Necrostatin-5 is rated 5.0 out of 5 by 1.
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Synonym: 2​[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,​3-​d]pyrimidin-2-yl]thio]-acetonitrile; Nec-5
Application: An inhibitor of necroptosis by indirect inhibition of RIP1 kinase
CAS Number: 337349-54-9
Molecular Weight: 383.49
Molecular Formula: C19H17N3O2S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Necrostatin-5 sc-215545 5 mg $60.00
Necrostatin-5 sc-215545A 25 mg $250.00

Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensation, organelle swelling, loss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1 partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5, since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1, but does not inhibit recombinant RIP1.


References

1. Degterev, A., et al. 2008. Nat. Chem. Biol. 4: 313-321. PMID: 18408713
2. Wang, K., et al. 2007. Bioorg. Med. Chem. Lett. 17: 1455-1465. PMID: 17270434

Physical State :
Solid
Solubility :
Soluble in DMSO: >10 mg/mL
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1913406
MDL Number :
MFCD01448275
SMILES :
COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4

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Certificate of Analysis

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Rated 5 out of 5 by from Wang et al Wang et al. (PubMed ID 17270434) found that Necrostatin-5 was a necroptosis inhibitor. -SCBT Publication Review
Date published: 2015-04-28
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