Necrostatin-1 inactive control A cell permeable thiohydantoin analog of Nec-1

Necrostatin-1, inactive control (CAS 64419-92-7)

Necrostatin-1, inactive control | CAS 64419-92-7 is rated 5.0 out of 5 by 1.
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Synonym: 5-(Indol-3-ylmethyl)-2-thiohydantoin; Nec-1i
Application: A cell permeable thiohydantoin analog of Nec-1
CAS Number: 64419-92-7
Purity: ≥95%
Molecular Weight: 245.30
Molecular Formula: C12H11N3OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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Necrostatin-1, Inactive Control is a cell-permeable N-demethylated thiohydantoin analog of Nec-1, devoid of anti-necroptotic properties and serves as a suitable inactive control.


References

1. Degterev, Alexei., et al., 2005. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature chemical biology. 1(2): 112-9. PMID: 16408008

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and methanol (5 mg/ml).
Storage :
Store at 4° C
Melting Point :
225.46° C (Predicted)
Boiling Point :
527.52° C (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
Jurkat : EC5050 = >10 µM (human)
pK Values :
pKa: 8.49, pKb: 0.89
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5371761
SMILES :
C1=CC=C2C(=C1)C(=CN2)CC3C(=O)NC(=S)N3

Download SDS (MSDS)

Certificate of Analysis

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Necrostatin-1 inactive control  Product Citations

See how others have used Necrostatin-1 inactive control. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 24746856  Vieira, M. et al. 2014. Neurobiology of disease. 68: 26-36.

PMID: # 21989986  Xiao, Y. et al. 2011. Blood. 118: 6057-67.

PMID: # 21978935  Jang, MS. et al. 2011. Cancer Res. 71: 7207-7215.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Paredes Paredes-Juarez GA; et al. (PubMed ID: 26419792) determined that Necrostatin-1, decreased the release of HMGB1 and its immune activation in MyD88 deficient cells. -SCBT Publication Review
Date published: 2015-06-27
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