Necrostatin-1 is a potent and selective inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.
1. Degterev, A., et al. 2005. Nat. Chem. Biol. 1: 112-119. PMID: 16408008
2. Degterev, A., et al. 2008. Nat. Chem. Biol. 4: 313-321. PMID: 18408713
3. He, W. et al. 2014. Oncogene. 33(23): 3004-3013. PMID: 23831571
See how others have used Necrostatin-1. Click on the entry to view the PubMed entry .
PMID: # 28968601
Fan, B. et al. 2017. Fangchinoline Induces Apoptosis, Autophagy and Energetic Impairment in Bladder Cancer. Cell. Physiol. Biochem.. 43: 1003-1011.
PMID: # 26911899
Tian, F. et al. 2016. 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Inhibits RIPK1/RIPK3-Dependent Necroptosis in THP-1-Derived Foam Cells. Scientific reports. 6: 21992.
PMID: # 26584462
Zeng, F. et al. 2016. Use of the rainbow trout cell lines, RTgill-W1 and RTL-W1 to evaluate the toxic potential of benzotriazoles. Ecotoxicology and environmental safety. 124: 315-23.
PMID: # 26787898
Guha, P. et al. 2016. Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Proceedings of the National Academy of Sciences of the United States of America. 113: 1417-22.
PMID: # 26935990
Wang, W. et al. 2016. Activation of innate antiviral immune response via double-stranded RNA-dependent RLR receptor-mediated necroptosis. Scientific reports. 6: 22550.
PMID: # 26936128
Tian, W. et al. 2016. mTOR signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeability transition in honokiol-triggered regulated necrosis. Mol Med Rep. 13: 3227-35.
PMID: # 26259235
Wang, Y. et al. 2015. PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death. Oncotarget. 6: 25252-65.
PMID: # 26100518
Lin, PH. et al. 2015. N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting. J. Biomed. Sci.. 22: 44.
PMID: # 26000607
Zhang, M. et al. 2015. The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells. PloS one. 10: e0127386.
PMID: # 26097885
Eling, N. et al. 2015. Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience. 2: 517-32.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.