NDSB-256 A nondetergent sulfobetaines class member

NDSB-256 (CAS 81239-45-4)

NDSB-256 | CAS 81239-45-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_5, d_23, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204120, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 79ms
  • REVIEWS, PRODUCT
Application: A nondetergent sulfobetaines class member
CAS Number: 81239-45-4
Purity: >99%
Molecular Weight: 257.4
Molecular Formula: C12H19NO3S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

NDSB-256 is a nondetergent sulfobetaines class member. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to isolate nuclear proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb near UV range significantly. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. NDSBs can be easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.


References

1. Goldberg, M.E., et al. 1996. Fold Des. 1: 21-27.

Physical State :
Solid
Solubility :
Soluble in water (10 g/l) at 20° C, and methanol.
Storage :
Store at room temperature
Melting Point :
245-250° C
Boiling Point :
551.06° C (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
4386830
MDL Number :
MFCD00225018
Beilstein Registry :
9194882
SMILES :
C[N+](C)(CCCS(=O)(=O)[O-])CC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

NDSB-256  Product Citations

See how others have used NDSB-256. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 16361259  Gross, CH. et al. 2006. J. Biol. Chem. 281: 4058-4068.

PMID: # 14645010  Garcia, A. et al. 2003. Blood. 103: 2088-95.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 52ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Gross Gross, CH. et al. (PubMed 16361259) successfully used NDSB-256 to refold denatured CFTR NBD proteins. -SCBT Publication Review
Date published: 2015-05-13
  • y_2019, m_5, d_23, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204120, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 69ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.