NDSB-195 A nondetergent sulfobetaine used to solubilize proteins

NDSB-195 (CAS 160255-06-1)

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Synonym: Dimethylethylammonium Propane Sulfonate; 3-[ethyl(dimethyl)azaniumyl]propane-1-sulfonate
Application: A nondetergent sulfobetaine used to solubilize proteins
CAS Number: 160255-06-1
Purity: ≥95%
Molecular Weight: 195.28
Molecular Formula: C7H17NO3S
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NDSB-195 is a member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, to isolate nuclear proteins, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. Reported to facilitate the renaturation of chemically and thermally denatured proteins and prevent protein aggregation. NDSBs can be easily removed by dialysis.


1. Vuillard, L., et al. 1994. FEBS Lett. 353: 294-296. PMID: 7957878
2. Vuillard, L., et al. 1995. Anal. Biochem. 230: 290-294. PMID: 7826351
3. Vuillard, L., et al. 1995. Biochem. J. 305: 337-343. PMID: 7826351
4. Goldberg, M.E., et al. 1996. Fold. Des. 1: 21-27. PMID: 9079360

Physical State :
Solubility :
Soluble in water.
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

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