Nadifloxacin is a cell-permeable, synthetic, broad-spectrum fluoroquinolone antibiotic that inhibits the growth of both gram-positive and gram-negative microbes. Studies suggest that the mechanism of inhibition occurs by interfering with DNA replication. Specifically Nadifloxacin suppresses gram-positive bacterial growth by targeting topoisomerase IV and suppresses gram-negative bacteria by inhibiting Topo II (DNA gyrase), which both function to relax postive supercoils before DNA replication. Furthermore, Nadifloxacin can decrease superoxide radical anions such as O2- and OH-, produced by neutrophils.
1. Akamatsu, H., et al. 1995. J. Int. Med. Res. 23: 19-26. PMID: 7774755 2. Kuwahara, K., et al. 2005. J. Dermatol. Sci. 38: 47-55. PMID: 15795123 3. Oppegard, L.M., et al. 2010. Antimicrob. Agents Chemother. 54: 3011-3014. PMID: 20404126
Soluble in DMSO (20 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Store at -20° C
~624.9° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
n20D 1.67 (Predicted)
DNA gyrase: IC50 = 10 ug.mL-1 (staphylococcus aureus subsp. aureus Mu50); Topoisomerase IV subunit A: IC50 >10 ug.mL-1 (staphylococcus aureus)
pKa: 5.65, pKb: 1.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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