N-(p-Coumaroyl) Serotonin is an antibacterial agent which inhibits the production of proinflammatory cytokines by LPS-stimulated human blood monocytes. It is believed that this inhibition is a result of the partial down-regulation of cytokine mRNA levels and inhibition of NF-κB activation. Studies indicate that serotonin is essential in protecting NK cells from apoptosis. In addition, these studies show that N-(p-Coumaroyl) Serotonin is essential in the oxidation of unsaturated fatty acids. N-(p-Coumaroyl) Serotonin functions as an antioxidant, inhibiting the effects of high glucose-induced cell death, caspase-9 activation, and the overproduction of the mitochondrial superoxide.
1. Takii, T., et al. 2003. Int. Immunopharmacol. 3: 273-277. PMID: 12586608 2. Piga, R., et al. 2009. Br. J. Nutr. 102: 264-272. PMID: 19222875 3. Piga, R., et al. 2010. Br. J. Nutr. 103: 25-31. PMID: 19747415
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
bvseo_sdk, java_sdk, bvseo-3.2.0
CLOUD, getContent, 73ms
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
PigaPiga, R. et al. (PubMed 19747415) investigated the protective effects of serotonin derivatives on glucose-induced damage in PC12 rat pheochromocytoma cells. They found that N-(p-Coumaroyl) Serotonin exerted a protective effect on high glucose-induced cell death, inhibited the activation of caspase-3, and inhibited the overproduction of the mitochondrial superoxide. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.