n-Octylglucoside A mild, non-denaturing detergent for the solubilization and reconstitution of membrane-bound proteins

n-Octylglucoside (CAS 29836-26-8)

n-Octylglucoside | CAS 29836-26-8 is rated 5.0 out of 5 by 1.
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Synonym: OG; Octyl-Glucoside
Application: A mild, non-denaturing detergent for the solubilization and reconstitution of membrane-bound proteins
CAS Number: 29836-26-8
Purity: ≥98%
Molecular Weight: 292.4
Molecular Formula: C14H28O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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n-Octylglucoside is a mild and non-denaturing detergent for the solubilization and reconsititution of membrane bound proteins. Most notable for its ability to be readily removed from final protein extracts via dialysis or gel filtration; this ability is due to n-Octylglucoside's high critical micelle concentration (CMC). The CMC value indicates a detergent's strength of hydrophobic binding and how readily molecules are incorporated into the micelle. Also useful in 2D electrophoresis and in an immunoprecipitation buffer for the immunopurification of phospho-tyrosine peptides.


References

1. Petri, W.A. and Wagner, R.R. 1979. J. Biol. Chem. 254: 4313-4316. PMID: 220238
2. Lambot, M., et al. 2002. J. Biol. Chem. 277: 20625-20630. PMID: 11937498
3. Zhang, G. and Neubert, T.A. 2006. Proteomics. 6: 571-578. PMID: 16342243

Usage :
Recommended working concentration for solubilizing and purifying proteins: 46 mM.
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
103-104° C
Boiling Point :
~454.11° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
Optical Activity :
α20/D -27°, c = 1 in methanol
IC50 :
BK polyomavirus: EC5050 = >100 µM
pK Values :
pKa: 12.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
62852
Merck Index :
14: 6767
MDL Number :
MFCD00063288
EC Number :
249-887-8
Beilstein Registry :
84118
SMILES :
CCCCCCCCO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O

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Certificate of Analysis

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n-Octylglucoside  Product Citations

See how others have used n-Octylglucoside. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 15951525  Billecke, C. et al. 2006. Mol. Cell Proteomics. 5: 35-42.

PMID: # 15867174  Tojo, T. et al. 2005. Circulation. 111: 2347-2355.

PMID: # 15328152  Wysoczynski M, et al. 2005. Blood. 105(1): 40-48.

PMID: # 15554924  Lebedeva, T. et al. 2004. Immunology. 113: 460-471.

PMID: # 12690105  Doucey, MA. et al. 2003. J. Biol. Chem. 278: 26983-26991.

PMID: # 11854520  Essler, M. et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 2252-2257.

PMID: # 12176037  Caselli, A. et al. 2002. Biochem. Biophys. Res. Commun. 296: 692-697.

PMID: # 11179295  Nusrat, A. et al. 2001. Infect. Immun. 69: 1329-1336.

PMID: # 11755955  Mustonen, P. et al. 2001. Thromb. Res. 104: 439-449.

PMID: # 10887180  Nusrat, A. et al. 2000. J. Biol. Chem. 275: 29816-29822.

Citations 1 to 10 of 11 total
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Rated 5 out of 5 by from Various publications site the use of n Various publications site the use of n-Octylglucoside as a detergent in their lysis buffer. -SCBT Publication Review
Date published: 2015-04-22
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