N-Desmethylclozapine (NDMC), a major metabolite of clozapine (sc-200402), has been found to act as an antagonist of phosphoinositide hydrolysis stimulated by serotonin receptors. NDMC has been shown to be a potent antagonist of SR-2C (aka: 5HT2C), and has been reported to act as a moderate agonist of the rat native and human recombinant mAChR M1(CHRM1). N-Desmethylclozapine is an activator of D2DR and D3DR.
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See how others have used N-Desmethylclozapine. Click on the entry to view the PubMed entry .
PMID: # 31108875 Anderson, AG.|Gaffy, CB.|Weseli, JR.|Gorres, KL.| et al. 2019. Viruses. 11:
PMID: # 21394453 Wohlfarth, A. et al. 2011. Anal Bioanal Chem. 400: 737-46.
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