N-Desmethylclozapine N-Desmethylclozapine is a major metabolite of clozapine (sc-200402), found to act as a potent antagonist of SR-2C, and a moderate agonist of mAChR M1.

N-Desmethylclozapine  (CAS 6104-71-8)

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Synonym: Norclozapine
Application: A metabolite of clozapine and neurotransmitter
CAS Number: 6104-71-8
Purity: 99%
Molecular Weight: 312.8
Molecular Formula: C17H17ClN4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

N-Desmethylclozapine sc-201113 5 mg $83.00
N-Desmethylclozapine sc-201113A 25 mg $328.00

N-Desmethylclozapine (NDMC), a major metabolite of clozapine (sc-200402), has been found to act as an antagonist of phosphoinositide hydrolysis stimulated by serotonin receptors. NDMC has been shown to be a potent antagonist of SR-2C (aka: 5HT2C), and has been reported to act as a moderate agonist of the rat native and human recombinant mAChR M1(CHRM1). N-Desmethylclozapine is an activator of D2DR and D3DR.


1. Kuoppamäki, M., et al. 1993. Eur. J. Pharmacol. 245: 179-182. PMID: 8387927
2. Thomas, D.R., et al. 2010. Neuropharmacology. 58: 1206-1214. PMID: 20206188

Physical State :
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (>44 mg/ml), chloroform, and methanol.
Storage :
Store at room temperature
Melting Point :
183-184° C
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
HERG: IC50 = 4490 nM (human); Muscarinic acetylcholine receptor M1: EC5050 = 18 nM (human)
Ki Data :
Muscarinic acetylcholine receptor M5: Ki= 51 nM (human); Muscarinic acetylcholine receptor M3: Ki= 90 nM (human)
pK Values :
pKb: 8.50
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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