N-Desmethylclozapine (NDMC), a major metabolite of clozapine (sc-200402), has been found to act as an antagonist of phosphoinositide hydrolysis stimulated by serotonin receptors. NDMC has been shown to be a potent antagonist of SR-2C (aka: 5HT2C), and has been reported to act as a moderate agonist of the rat native and human recombinant mAChR M1(CHRM1). N-Desmethylclozapine is an activator of D2DR and D3DR.
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2. Thomas, D.R., et al. 2010. Neuropharmacology. 58: 1206-1214. PMID: 20206188
Soluble in ethanol (25 mg/ml), DMSO (>44 mg/ml), chloroform, and methanol.
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