N-Arachidonoyl-L-serineAn endocannabinoid-like compound and CB1/CB2 agonist

N-Arachidonoyl-L-serine (CAS 187224-29-9)

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Synonym: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine
Application: An endocannabinoid-like compound and CB1/CB2 agonist
CAS Number: 187224-29-9
Purity: ≥98%
Molecular Weight: 391.54
Molecular Formula: C23H37NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Arachidonoyl-L-serine is an endocannabinoid-like brain constituent with similar biological profile like abnormal cannabidiol. Binds weakly to CB1 and CB2 receptors and TRPV1. Produces endothelium-dependent vasodilation. Increases phosphorylation of Akt and mitogen-activated protein.


References

1. Milman, G., et al. 2006. Proc Natl Acad Sci USA. 103: 2428-2433. PMID: 16467152

Appearance :
Oil or viscous
Physical State :
Low-Melting Solid
Solubility :
Soluble in DMSO (≥20 mg/ml), DMF (≥20 mg/ml), PBS (pH 7.2) (≥2 mg/ml), water (2 mg/ml at 25.0° C), and ethanol.
Storage :
Store at -80° C
Refractive Index :
n20D 1.52 (Predicted)
Ki Data :
CB1: Ki>10 µM (human); CB2: Ki>10 µM (human)
pK Values :
pKa: 3.26 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10596625
MDL Number :
MFCD08062151
SMILES :
CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)N[C@@H](CO)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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N-Arachidonoyl-L-serine  Product Citations

See how others have used N-Arachidonoyl-L-serine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28102080  Wu, J. et al. 2017. J. Agric. Food Chem. 65: 1051-1057.

Citations 1 to 1 of 1 total
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