|PRODUCT NAME||CATALOG #||UNIT||PRICE||QTY||FAVORITES|
|N-Acetylprocainamide hydrochloride||sc-253092||1 g||$75.00||
Class III antiarrhythmic. This compound Increases the duration of the action potential by decreasing the delayed outward potassium current, slightly decreasing the calcium current, and slightly depressing the inward rectifier potassium current. This is the active metabolite of procainamide that does not induce systemic lupus erythematosus.
Geelen, P., et al., Concomitant block of the rapid (I(Kr)) and slow (I(Ks)) components of the delayed rectifier potassium current is associated with additional drug effects on lengthening of cardiac repolarization. J. Cardiovasc. Pharmacol. Ther. 4, 143, (1999) Richardson, B., et al., N-acetylprocainamide is a less potent inducer of T cell autoreactivity than procainamide. Arthritis Rheum. 31, 995-999, (1998) Komeichi, K., et al., Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytes. Eur. J. Pharmacol. 187, 313-322, (1990)
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