N-Acetylprocainamide hydrochloride Class III antiarrhythmic. This compound Increases the duration of the action potential by decreasing the delayed outward potassium current, slightly decreasing the calcium current, and slightly depressing the inward rectifier potassium current. This is the active metabolite of procainamide that does not induce systemic lupus erythematosus.

N-Acetylprocainamide hydrochloride  (CAS 34118-92-8)

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CAS Number: 34118-92-8
Molecular Weight: 313.82
Molecular Formula: C15H24ClN3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
N-Acetylprocainamide hydrochloride sc-253092 1 g $75.00

Class III antiarrhythmic. This compound Increases the duration of the action potential by decreasing the delayed outward potassium current, slightly decreasing the calcium current, and slightly depressing the inward rectifier potassium current. This is the active metabolite of procainamide that does not induce systemic lupus erythematosus.


References

Geelen, P., et al., Concomitant block of the rapid (I(Kr)) and slow (I(Ks)) components of the delayed rectifier potassium current is associated with additional drug effects on lengthening of cardiac repolarization. J. Cardiovasc. Pharmacol. Ther. 4, 143, (1999) Richardson, B., et al., N-acetylprocainamide is a less potent inducer of T cell autoreactivity than procainamide. Arthritis Rheum. 31, 995-999, (1998) Komeichi, K., et al., Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytes. Eur. J. Pharmacol. 187, 313-322, (1990)

Appearance :
Powder or crystalline powder
Physical State :
Solid
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71417
SMILES :
CCN(CC)CCNC(=O)C1=CC=C(C=C1)NC(=O)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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