N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.
1. Palacios, M., et al. 1989. Biochem. Biophys. Res. Commun. 165: 802-809. PMID: 2480784 2. Rees, D.D., et al. 1990. Br. J. Pharmacol. 101: 746-752. PMID: 1706208 3. McCall, T.B., et al. 1991. Br. J. Pharmacol. 102: 234-238. PMID: 1710525 4. Moore, W.M., et al. 1994. J. Med. Chem. 37: 3886-3888. PMID: 7525961
Rated 5 out of
Van SlootenVan Slooten, AR. et al. (PubMed 25745859) presented N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO) as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.