N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitroguanidine tris(trifluoroacetate) salt is a cell-permeable, potent and highly selective inhibitor of NOS1 (nNOS) (Ki = 120 nM) and displays >2500-fold and 320-fold selectivity over NOS3 (eNOS) and NOS2 (iNOS), respectively.
Soluble in water (50 mg/mL).
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Great inhibitorI wanted an nNOS inhibitor which didnot inhibit CYP2E1 as i was working with acetaminophen toxicity. After the checking its structure and other properties, I used the nNOS specific inhibitor and it worked out fine. It is a great product and can be used for nNOS specific inhibition.
Date published: 2016-11-30
Rated 5 out of
Hervera A; et alHervera A; et al. (PubMed ID: 20498253) determined that N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitroguanidine tris(trifluoroacetate) salt, a NOS1 inhibitor, suppressed neuropathic pain and increased the local effects of [d-Pen(2),d-Pen(5)]-enkephalin and (2-methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone. -SCBT Publication Review
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