N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-Nprime-nitroguanidine tris(trifluoroacetate) saltA cell-permeable, potent and highly selective inhibitor of NOS1 (nNOS)

N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt (CAS 357965-99-2)

N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt | CAS 357965-99-2 is rated 5.0 out of 5 by 2.
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Synonym: N-(4S)-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine tris(trifluoroacetate) salt
Application: A cell-permeable, potent and highly selective inhibitor of NOS1 (nNOS)
CAS Number: 357965-99-2
Purity: ≥95%
Molecular Weight: 589.37
Molecular Formula: C14H24N7O8F9
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitroguanidine tris(trifluoroacetate) salt is a cell-permeable, potent and highly selective inhibitor of NOS1 (nNOS) (Ki = 120 nM) and displays >2500-fold and 320-fold selectivity over NOS3 (eNOS) and NOS2 (iNOS), respectively.

Appearance :
powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/mL).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
71311606
MDL Number :
MFCD05865227
SMILES :
C(C[C@@H](CNCCN)N)CN=C(N)N[N+](=O)[O-].C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

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Certificate of Analysis

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N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-Nprime-nitroguanidine tris(trifluoroacetate) salt  Product Citations

See how others have used N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-Nprime-nitroguanidine tris(trifluoroacetate) salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26454079  Banerjee, S. et al. 2015. Free radical biology & medicine. 89: 750-7.

PMID: # 25527626  Villalba, N. et al. 2014. J Am Heart Assoc. 3: e001474.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Great inhibitor I wanted an nNOS inhibitor which didnot inhibit CYP2E1 as i was working with acetaminophen toxicity. After the checking its structure and other properties, I used the nNOS specific inhibitor and it worked out fine. It is a great product and can be used for nNOS specific inhibition.
Date published: 2016-11-30
Rated 5 out of 5 by from Hervera A; et al Hervera A; et al. (PubMed ID: 20498253) determined that N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitroguanidine tris(trifluoroacetate) salt, a NOS1 inhibitor, suppressed neuropathic pain and increased the local effects of [d-Pen(2),d-Pen(5)]-enkephalin and (2-methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone. -SCBT Publication Review
Date published: 2015-07-18
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