Myeloperoxidase Inhibitor-I An irreversible and specific inhibitor of the peroxidation activity of MPO

Myeloperoxidase Inhibitor-I (CAS 5351-17-7)

Myeloperoxidase Inhibitor-I | CAS 5351-17-7 is rated 5.0 out of 5 by 1.
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Synonym: 4-Aminobenzoic hydrazide
Application: An irreversible and specific inhibitor of the peroxidation activity of MPO
CAS Number: 5351-17-7
Purity: >98%
Molecular Weight: 151.17
Molecular Formula: C7H9N3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Myeloperoxidase Inhibitor-I is a benzoic acid hydrazide analog acting as an irreversible and specific inhibitor of the peroxidation activity of MPO. Myeloperoxidase Inhibitor-I shows no effect in inhibition of catalase or glutathione peroxidase activities. Shows no effect on the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60.


References

Engelmann, I., et al. 2000. Redox Report 5, 207. Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461. Burner, U., et al. 1999. J. Biol. Chem. 274, 9494. Kettle, A.J., et al. 1997. Biochem. J. 321, 503. Kettle, A.J., et al. 1995. Biochem. J. 308, 559.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible).
Storage :
Store at -20° C
Melting Point :
225-227° C (lit.)
Density :
1.27 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
MPO: IC50 = 300 nM; HOCl production : IC50 = 16 µM (zymosan); HOCl production : IC50 = 2.2 µM ( phorbol myristate acetate stimulated neutrophils)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DG2580000
PubChem CID :
21450
MDL Number :
MFCD00007606
EC Number :
226-324-4
Beilstein Registry :
639053
SMILES :
C1=CC(=CC=C1C(=O)NN)N

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Certificate of Analysis

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Rated 5 out of 5 by from Wang Q; et al Wang Q; et al. (PubMed ID: 25024373) determined that Myeloperoxidase Inhibitor-I prevented HFD-enhanced insulin resistance and decreased peroxidase activity of neutrophils. -SCBT Publication Review
Date published: 2015-02-23
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