Myeloperoxidase Inhibitor-I is a benzoic acid hydrazide analog acting as an irreversible and specific inhibitor of the peroxidation activity of MPO. Myeloperoxidase Inhibitor-I shows no effect in inhibition of catalase or glutathione peroxidase activities. Shows no effect on the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60.
Engelmann, I., et al. 2000. Redox Report 5, 207. Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461. Burner, U., et al. 1999. J. Biol. Chem. 274, 9494. Kettle, A.J., et al. 1997. Biochem. J. 321, 503. Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible).
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Wang Q; et alWang Q; et al. (PubMed ID: 25024373) determined that Myeloperoxidase Inhibitor-I prevented HFD-enhanced insulin resistance and decreased peroxidase activity of neutrophils. -SCBT Publication Review
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