Muscone, originally collected from male musk deer ventral glands, is a potent antiinflammatory agent that has been reported to reduce proinflammatory cytokines in vitro. This compound has also been shown to reverse IL-1β-induced upregulation of IL-1β, TNFα, NOS2 (inducible nitric oxide synthase), Cox-2, aggrecanase 2, matrix metalloproteinase, and nitric oxide. In rat liver, Muscone has been shown to induce CYP4F3 (cytochrome P-450) and to inhibit glutamate-induced apoptosis in PC-12 cells via maintenance of mitochondral membrane potential and inhibition of intracellular Ca2+ overload. Additional studies have reported Muscone to be weakly estrogenically active in vitro.
1. Tanaka, E., et al. 1991. Biochem. Pharmacol. 41: 472-473. PMID: 1994906 2. Bitsch, N., et al. 2002. Arch. Environ. Contam. Toxicol. 43: 257-264. PMID: 12202919 3. Lin, D.L., et al. 2004. J. Forensic Sci. 49: 1187-1193. PMID: 15568689 4. Matsuda, H., et al. 2008. Chem. Biodivers. 5: 1023-1033. PMID: 18618396 5. Sun, R., et al. 2009. Zhongguo Zhong Yao Za Zhi. 34: 1701-1704. PMID: 19873786 6. Liang, Q.Q., et al. 2010. Clin. Orthop. Relat. Res. 46: 1600-1610. PMID: 19763723
Soluble in ethanol (25 mg/mL), and acetone.
Store at room temperature
~51.13° C (Predicted)
~329.5° C at 760 mmHg (Predicted)
~0.8 g/mL (Predicted)
n20D 1.44 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Wang GY; et alWang GY; et al. (PubMed ID: 25976179) determined that Muscone, the main chemical in the smell of Musk, crossed the blood-brain barrier (BBB) and inhibits MMP-9 and P-gp. -SCBT Publication Review
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