Muscone A potent antiinflammatory agent, cytrochrome P-450 inducer, and apoptosis inhibitor

Muscone (CAS 541-91-3)

Muscone | CAS 541-91-3 is rated 5.0 out of 5 by 1.
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Synonym: 3-Methylcyclopentadecanone; Musk ketone
Application: A potent antiinflammatory agent, cytrochrome P-450 inducer, and apoptosis inhibitor
CAS Number: 541-91-3
Purity: ≥98%
Molecular Weight: 238.4
Molecular Formula: C16H30O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Muscone, originally collected from male musk deer ventral glands, is a potent antiinflammatory agent that has been reported to reduce proinflammatory cytokines in vitro. This compound has also been shown to reverse IL-1β-induced upregulation of IL-1β, TNFα, NOS2 (inducible nitric oxide synthase), Cox-2, aggrecanase 2, matrix metalloproteinase, and nitric oxide. In rat liver, Muscone has been shown to induce CYP4F3 (cytochrome P-450) and to inhibit glutamate-induced apoptosis in PC-12 cells via maintenance of mitochondral membrane potential and inhibition of intracellular Ca2+ overload. Additional studies have reported Muscone to be weakly estrogenically active in vitro.


References

1. Tanaka, E., et al. 1991. Biochem. Pharmacol. 41: 472-473. PMID: 1994906
2. Bitsch, N., et al. 2002. Arch. Environ. Contam. Toxicol. 43: 257-264. PMID: 12202919
3. Lin, D.L., et al. 2004. J. Forensic Sci. 49: 1187-1193. PMID: 15568689
4. Matsuda, H., et al. 2008. Chem. Biodivers. 5: 1023-1033. PMID: 18618396
5. Sun, R., et al. 2009. Zhongguo Zhong Yao Za Zhi. 34: 1701-1704. PMID: 19873786
6. Liang, Q.Q., et al. 2010. Clin. Orthop. Relat. Res. 46: 1600-1610. PMID: 19763723

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (25 mg/mL), and acetone.
Storage :
Store at room temperature
Melting Point :
~51.13° C (Predicted)
Boiling Point :
~329.5° C at 760 mmHg (Predicted)
Density :
~0.8 g/mL (Predicted)
Refractive Index :
n20D 1.44 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
GY0950000
PubChem CID :
10947
MDL Number :
MFCD00211114
EC Number :
208-795-8
SMILES :
CC1CCCCCCCCCCCCC(=O)C1

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Muscone  Product Citations

See how others have used Muscone. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 21856397  Wu, Q. et al. 2011. Journal of ethnopharmacology. 138: 34-9.

PMID: # 21856397  Wu, Q. et al. 2011. Journal of ethnopharmacology. 138: 34-9.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Wang GY; et al Wang GY; et al. (PubMed ID: 25976179) determined that Muscone, the main chemical in the smell of Musk, crossed the blood-brain barrier (BBB) and inhibits MMP-9 and P-gp. -SCBT Publication Review
Date published: 2015-06-07
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