MTSEA-FluoresceinA thiol specific fluorescent probe

MTSEA-Fluorescein (CAS 1356019-48-1)

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Synonym: (R)-2-Amino-2-[(5-fluoresceinyl)aminocarbonyl]ethyl Methanethiosulfonate, Trifluoroacetic Acid Salt
Application: A thiol specific fluorescent probe
CAS Number: 1356019-48-1
Molecular Weight: 642.58
Molecular Formula: C26H21F3N2O10S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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MTSEA-Fluorescein is a thiol specific fluorescent probe useful for protein topology and ion channel research. MTS-fluorophores may be useful in the real-time monitoring of conformational changes. MTS compounds have been shown to irreversibly activate the BNC1-G430C neuronal cation channel only when the channel was activated by protons. This suggests that fluorescent MTS reagents may be used as reporters of cell surface localization as well as the functional status of ion channels.


References

1. Mannuzzu, L.M., et al. 1996. Science. 271: 213-216. PMID: 8539623
2. Goulet, C.C., et al. 1998. J. Biol. Chem. 273: 30012-30017. PMID: 9792722
3. Adams, C.M., et al. 1998. J. Biol. Chem. 273: 30204-30207. PMID: 9804777

Physical State :
Solid
Solubility :
Soluble in DMSO, Ethanol and Methanol
Storage :
Store at -20° C
Melting Point :
>130° C (dec.)
Fluoresence :
λex 492 nm, λem 515 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71313256
SMILES :
CS(=O)(=O)SC[C@@H](C(=O)NC1=CC(=C(C=C1)C2=C3C=CC(=O)C=C3OC4=C2C=CC(=C4)O)C(=O)O)N.C(=O)(C(F)(F)F)O

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Certificate of Analysis

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MTSEA-Fluorescein  Product Citations

See how others have used MTSEA-Fluorescein. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 9804777  Adams, CM. et al. 1998. J. Biol. Chem. 273: 30204-30207.

Citations 1 to 1 of 1 total
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