MreB Perturbing Compound A22 is a cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. MreB Perturbing Compound A22 is known to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.
Gitai, Z., et al. 2005. Cell 120, 329. Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167. Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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NoguchiNoguchi, N. et al. (PubMed 18591769) reported an anti-infectious effect of S-benzylisothiourea Compound A22, which inhibits the actin-like protein, MreB, in Shigella flexneri. -SCBT Publication Review
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