MreB Perturbing Compound A22 An isothiourea that reversibly perturbs MreB function

MreB Perturbing Compound A22 (CAS 22816-60-0)

MreB Perturbing Compound A22 | CAS 22816-60-0 is rated 5.0 out of 5 by 1.
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Application: An isothiourea that reversibly perturbs MreB function
CAS Number: 22816-60-0
Purity: ≥90%
Molecular Weight: 271.6
Molecular Formula: C8H8Cl2N2S HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

MreB Perturbing Compound A22 is a cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. MreB Perturbing Compound A22 is known to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.


References

Gitai, Z., et al. 2005. Cell 120, 329. Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167. Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml), and water (2 mg/ml).
Storage :
Store at 4° C
Boiling Point :
347.7° C at 760 mmHg (Predicted)
IC50 :
Indoleamine-2,3-dioxygenase: IC50 = 7300 nM (human A431 cells)
pK Values :
pKb: 8.19
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2830968
MDL Number :
MFCD00035050
SMILES :
C1=CC(=C(C=C1CSC(=N)N)Cl)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Noguchi Noguchi, N. et al. (PubMed 18591769) reported an anti-infectious effect of S-benzylisothiourea Compound A22, which inhibits the actin-like protein, MreB, in Shigella flexneri. -SCBT Publication Review
Date published: 2015-04-15
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