Moxifloxacin Hydrochloride An antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV

Moxifloxacin Hydrochloride (CAS 186826-86-8)

Moxifloxacin Hydrochloride | CAS 186826-86-8 is rated 5.0 out of 5 by 1.
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Synonym: Actura; Avalox; Avelox
Application: An antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV
CAS Number: 186826-86-8
Purity: ≥99%
Molecular Weight: 437.89
Molecular Formula: C21H24FN3O4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Moxifloxacin Hydrochloride is the hydrochloride salt preparation of Moxifloxacin, an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive and gram-negative strains. 8-methoxy-fluoroquinones are described to inhibit the activities of Topo II (DNA gyrase) and topoisomerase IV. The 8-methoxy group of Moxifloxacin is suggested to confer a lowered propensity for resistance development as compared to other C-8 substituted quinolones, and Moxifloxacin demonstrates potent activity against wild-type and first-step gyrase- and topoisomerase IV-resistant mutants. Moxifloxacin shows activity against methicillin-susceptible staphylococci, penicillin-susceptible and penicillin-resistant pneumococci, penicillin-susceptible and penicillin-resistant viridans group streptococci, group A streptococci, M. catarrhalis, and H. influenzae in vitro.


References

1. Souli, M., et al. 1998. Int. J. Antimicrob. Agents. 10: 23-30. PMID: 9624540
2. Ballow, C., et al. 1999. Clin Ther. 21: 513-522. PMID: 10321420
3. Dalhoff, A., 2001. Clin. Infect. Dis. 32: S16-S22. PMID: 11249824
4. Dalhoff, A., et al. 2001. Clin. Infect. Dis. 32: S22-S29. PMID: 11249825
5. Kishii, R., et al. 2003. Antimicrob. Agents Chemother. 47: 77-81. PMID: 12499172

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (24 mg/ml), DMSO (88 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
323.9-325° C
Boiling Point :
636.4° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Streptokinase A: EC5050 = 171 nM (Streptococcus pyogenes serotype M1); Streptococcus sp. 'group A': EC5050 = 199 nM; DNA gyrase: IC50 = 300 nM (Escherichia coli K-12); Streptococcus: EC5050 = 358 nM; PhoP regulon: IC50 = 420 nM (Salmonella typhi)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
VB1983750
PubChem CID :
101526
MDL Number :
MFCD00949117
Beilstein Registry :
8377447
SMILES :
COC1=C2C(=CC(=C1N3C[C@@H]4CCCN[C@@H]4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl

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Certificate of Analysis

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Moxifloxacin Hydrochloride  Product Citations

See how others have used Moxifloxacin Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 29109700  Anes, J. et al. 2017. Front Microbiol. 8: 1913.

PMID: # 28840713  Domes, C. et al. 2017. Anal. Chem. 89: 9997-10003.

PMID: # 27138688  Lee, S. et al. 2016. Scientific reports. 6: 25339.

PMID: # 25385118  Ordas, A. et al. 2015. Antimicrob. Agents Chemother. 59: 753-62.

PMID: # 26094899  Shimokawa, Y. et al. 2015. Biological & pharmaceutical bulletin. 38: 1425-9.

PMID: # 25933967  Czyrski, A. et al. 2015. Pharmacol Rep. 67: 542-4.

PMID: # 24401394  Byzova, NA. et al. 2014. Talanta. 119: 125-32.

PMID: # 24532601  Adams, KN. et al. 2014. J. Infect. Dis. 210: 456-66.

PMID: # 22910339  Toncheva, A. et al. 2012. Eur J Pharm Sci. 47: 642-51.

Citations 1 to 9 of 9 total

What is the appearance of this compound?

Asked by: two2igm05
Thank you for your question. Moxifloxacin Hydrochloride, sc-205758, is a light yellow or yellow powder.
Answered by: TechService7
Date published: 2016-12-28
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Rated 5 out of 5 by from Received it very fast Received it very fast, used it in our experiments and it works great, happy with purchase.
Date published: 2015-06-04
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