Monosodium urate (crystals) Monosodium urate (crystals) is a cell permeable inflammatory compound that engages caspase-1-activiating cryopyrin inflammasome leading to the production of IL-1β and IL-18.

Monosodium urate (crystals)  (CAS 1198-77-2)

Monosodium urate (crystals) is rated 5.0 out of 5 by 1.
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| See 2 Citations
Synonym: Uric acid monosodium salt (crystals)
Application: A Cryopyrin inflammatory compound that induces IL-1β production
CAS Number: 1198-77-2
Molecular Weight: 190.10
Molecular Formula: C5H3N4O3•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Monosodium urate (crystals) sc-202711 2 mg $90.00

Monosodium urate has been reported to be an inflammatory compound. Mechanistic studies suggest that this compound intracellularly engages caspase-1-activating cryopyrin inflammasome, resulting in the production of active IL-1β and IL-18. Experiments have shown that monosodium urate crystals also induce triggering receptor expressed on myeloid cells 1 (TREM-1) expression in infiltrating leukocytes in a murine air-pouch model of crystal-induced acute inflammation. Monosodium urate is also an activator of cryopyrin.


References

1. Murakami, Y., et al. 2006. Arthritis Rheum. 54: 455-462. PMID: 16447220
2. Martinon, F., et al. 2006. Nature. 440: 237-241. PMID: 16407889
3. Giamarellos-Bourboulis, E.J., et al. 2009. Ann. Rheum. Dis. 68: 273-278. PMID: 18390571
4. Hoffman, H.M., et al. 2010. Arthritis Rheum. 62: 2170-2179. PMID: 20506351

Usage :
Solution may appear as a slightly hazy suspension.
Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in 1M NaOH (25 mg/ml), and PBS.
Storage :
Store at -20° C
Refractive Index :
n20D ~1.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YU7062000
PubChem CID :
16220071
MDL Number :
MFCD00067310
EC Number :
214-838-1
SMILES :
C12=C(NC(=O)N1)NC(=O)NC2=O.[Na+]

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Certificate of Analysis

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See how others have used Monosodium urate (crystals). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24121974
Liu, W. et al. 2014. OxLDL-induced IL-1 beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation. Inflamm. Res.. 63: 33-43.

PMID: # 24574460
Taylor, A. et al. 2014. SRF is required for neutrophil migration in response to inflammation. Blood. 123: 3027-36.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Blum Blum, et al. (PubMed ID 26327312) found that three MPEC strains (mastitis pathogenic strains) were able to metabolize uric acid as a source of nitrogen. Based on this, the author extrapolates that this ability to metabolize uric acid is advantageous to MPEC for defense against uric acid in mammary alveoli (oxidative antimicrobrial defense in milk). -SCBT Publication Review
Date published: 2015-06-11
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