MnTBAP chloride A cell permeable superoxide dismutase mimetic and peroxynitrite scavenger

MnTBAP chloride (CAS 55266-18-7)

MnTBAP chloride | CAS 55266-18-7 is rated 5.0 out of 5 by 1.
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Synonym: Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
Application: A cell permeable superoxide dismutase mimetic and peroxynitrite scavenger
CAS Number: 55266-18-7
Purity: ≥97%
Molecular Weight: 879.15
Molecular Formula: C48H28MnN4O8•Cl
* Refer to Certificate of Analysis for lot specific data (including water content).
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MnTBAP chloride is a cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.A potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). In addition, it protects endothelial cells in a dose-dependent manner (EC50 ~40 μM) against paraquat (2 mM) and inhibits the oxidation of Dihydrorhodamine 123 by peroxynitrite.


References

1. Faulkner, K.M. et al., J. Biol. Chem. 269, 23471, (1994) 2. Day, B.J. et al., J. Pharm. Exp. Ther. 275, 1227, (1995) 3. Szabó, C. et al., FEBS Lett. 381, 82, (1996) 4. Ghafourifar, P. et al., J. Biol. Chem. 274, 31185, (1999) 5. Hildeman, D.A. et al., Immunity 10, 735, (1999) 6. Kotamraju, S. et al., J. Biol. Chem. 275, 33585, (2000) 7. R. Motterlini, et al., J. Biol. Chem. 275, 13613, (2000) 8. Dussmann, H. et al., J. Biol. Chem. 278, 12645, (2003)

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760566
SMILES :
C1=CC(=CC=C1C2=C3C=CC(=C(C4=NC(=C(C5=CC=C([N-]5)C(=C6C=CC2=N6)C7=CC=C(C=C7)C(=O)O)C8=CC=C(C=C8)C(=O)O)C=C4)C9=CC=C(C=C9)C(=O)O)[N-]3)C(=O)O.[Cl-].[Mn+3]

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Certificate of Analysis

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MnTBAP chloride  Product Citations

See how others have used MnTBAP chloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 28545464  Salcher, S. et al. 2017. Mol. Cancer. 16: 95.

PMID: # 28720506  Hsieh, YP. et al. 2017. Journal of the Formosan Medical Association = Taiwan yi zhi.

PMID: # 28779175  Tang, T. et al. 2017. Nat Commun. 8: 202.

PMID: # 26821068  Evans, MK. et al. 2016. Cell Death Dis. 7: e2073.

PMID: # 27154977  Rahman, A. et al. 2016. Free Radic. Biol. Med. 96: 273-89.

PMID: # 27931237  Yao, N. et al. 2016. J. Exp. Clin. Cancer Res. 35: 192.

PMID: # 27327130  Pace, C. et al. 2016. Toxicol In Vitro. 35: 188-201.

PMID: # 26902808  Yuan, Y. et al. 2016. Free Radic. Res. 50: 627-37.

PMID: # 25757953  Li, Y. et al. 2015. Acta Biochim. Biophys. Sin. (Shanghai). 47: 306-12.

PMID: # 25993470  Macconi, D. et al. 2015. PLoS ONE. 10: e0127172.

Citations 1 to 10 of 22 total
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Rated 5 out of 5 by from Al Kfaji et al Al Kfaji et al. (PubMed ID 26251331) found that MnTBAP chloride reduced ROS production and reversed changes in mitochondrial function in human renal mesangial cells. -SCBT Publication Review
Date published: 2015-01-11
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