MnTBAP chloride is a cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.A potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). In addition, it protects endothelial cells in a dose-dependent manner (EC50 ~40 μM) against paraquat (2 mM) and inhibits the oxidation of Dihydrorhodamine 123 by peroxynitrite.
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Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Al Kfaji et alAl Kfaji et al. (PubMed ID 26251331) found that MnTBAP chloride reduced ROS production and reversed changes in mitochondrial function in human renal mesangial cells. -SCBT Publication Review
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