MnTBAP chloride A cell permeable superoxide dismutase mimetic and peroxynitrite scavenger

MnTBAP chloride (CAS 55266-18-7)

MnTBAP chloride | CAS 55266-18-7 is rated 5.0 out of 5 by 1.
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| See product citations (22)
Synonym: Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
Application: A cell permeable superoxide dismutase mimetic and peroxynitrite scavenger
CAS Number: 55266-18-7
Purity: ≥97%
Molecular Weight: 879.15
Molecular Formula: C48H28MnN4O8•Cl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
MnTBAP chloride sc-221954 10 mg $33.00
MnTBAP chloride sc-221954A 50 mg $90.00

MnTBAP chloride is a cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.A potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). In addition, it protects endothelial cells in a dose-dependent manner (EC50 ~40 μM) against paraquat (2 mM) and inhibits the oxidation of Dihydrorhodamine 123 by peroxynitrite.


References

1. Faulkner, K.M. et al., J. Biol. Chem. 269, 23471, (1994) 2. Day, B.J. et al., J. Pharm. Exp. Ther. 275, 1227, (1995) 3. Szabó, C. et al., FEBS Lett. 381, 82, (1996) 4. Ghafourifar, P. et al., J. Biol. Chem. 274, 31185, (1999) 5. Hildeman, D.A. et al., Immunity 10, 735, (1999) 6. Kotamraju, S. et al., J. Biol. Chem. 275, 33585, (2000) 7. R. Motterlini, et al., J. Biol. Chem. 275, 13613, (2000) 8. Dussmann, H. et al., J. Biol. Chem. 278, 12645, (2003)

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760566
SMILES :
C1=CC(=CC=C1C2=C3C=CC(=C(C4=NC(=C(C5=CC=C([N-]5)C(=C6C=CC2=N6)C7=CC=C(C=C7)C(=O)O)C8=CC=C(C=C8)C(=O)O)C=C4)C9=CC=C(C=C9)C(=O)O)[N-]3)C(=O)O.[Cl-].[Mn+3]

Download SDS (MSDS)

Certificate of Analysis

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MnTBAP chlorideProduct Citations

See how others have used MnTBAP chloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 28545464
Salcher, S. et al. 2017. C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. Mol. Cancer. 16: 95.

PMID: # 28720506
Hsieh, YP. et al. 2017. Arecoline activates latent transforming growth factor β1 via mitochondrial reactive oxygen species in buccal fibroblasts: Suppression by epigallocatechin-3-gallate. Journal of the Formosan Medical Association = Taiwan yi zhi.

PMID: # 28779175
Tang, T. et al. 2017. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 8: 202.

PMID: # 26821068
Evans, MK. et al. 2016. X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity. Cell Death Dis. 7: e2073.

PMID: # 27154977
Rahman, A. et al. 2016. Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine. Free Radic. Biol. Med.. 96: 273-89.

PMID: # 27931237
Yao, N. et al. 2016. A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells. J. Exp. Clin. Cancer Res.. 35: 192.

PMID: # 27327130
Pace, C. et al. 2016. Monomethylarsonous acid, but not inorganic arsenic, is a mitochondria-specific toxicant in vascular smooth muscle cells. Toxicol In Vitro. 35: 188-201.

PMID: # 26902808
Yuan, Y. et al. 2016. A vital role for myosin-9 in puromycin aminonucleoside-induced podocyte injury by affecting actin cytoskeleton. Free Radic. Res.. 50: 627-37.

PMID: # 25757953
Li, Y. et al. 2015. Sirt3-MnSOD axis represses nicotine-induced mitochondrial oxidative stress and mtDNA damage in osteoblasts. Acta Biochim. Biophys. Sin. (Shanghai). 47: 306-12.

PMID: # 25993470
Macconi, D. et al. 2015. Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. PLoS ONE. 10: e0127172.

Citations 1 to 10 of 22 total
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Rated 5 out of 5 by from Al Kfaji et al Al Kfaji et al. (PubMed ID 26251331) found that MnTBAP chloride reduced ROS production and reversed changes in mitochondrial function in human renal mesangial cells. -SCBT Publication Review
Date published: 2015-01-11
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