MK-2206 is a highly selective inhibitor of Akt1, Akt2, and Akt3 with IC50 values of 8 nM, 12 nM and 65 nM, respectively. MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib (sc-202154) or lapatinib (sc-353658) in lung NCI-H460 or ovarian A2780 tumor cells.
See how others have used MK-2206 dihydrochloride. Click on the entry to view the PubMed entry .
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