MK-2206 dihydrochloride A highly selective pan-Akt inhibitor activated by the pleckstrin homology domain

MK-2206 dihydrochloride (CAS 1032350-13-2)

MK-2206 dihydrochloride | CAS 1032350-13-2 is rated 5.0 out of 5 by 1.
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Application: A highly selective pan-Akt inhibitor activated by the pleckstrin homology domain
CAS Number: 1032350-13-2
Molecular Weight: 480.39
Molecular Formula: C25H21N5O•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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MK-2206 is a highly selective inhibitor of Akt1, Akt2, and Akt3 with IC50 values of 8 nM, 12 nM and 65 nM, respectively. MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib (sc-202154) or lapatinib (sc-353658) in lung NCI-H460 or ovarian A2780 tumor cells.

Physical State :
Solid
Solubility :
Soluble in DMSO (14 mg/ml at 25 °C), water (1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Storage :
Store at -20° C
Melting Point :
>225° C (dec.)
Refractive Index :
n20D ~1.76 (Predicted)
IC50 :
Akt1: IC50 = 8 nM; Akt2: IC50 = 12 nM; Akt3: IC50 = 65 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46930998
MDL Number :
MFCD14584463
SMILES :
C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl

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Certificate of Analysis

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MK-2206 dihydrochloride  Product Citations

See how others have used MK-2206 dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 15 total

PMID: # 28759639  Schlegel, P. et al. 2017. PLoS ONE. 12: e0182110.

PMID: # 28012535  Youn, CK. et al. 2017. Int. J. Pediatr. Otorhinolaryngol. 92: 61-66.

PMID: # 27990618  Ok, SH. et al. 2017. Cardiovasc. Toxicol. 17: 344-354.

PMID: # 25686839  McKee, CM. et al. 2015. Oncotarget. 6: 3784-96.

PMID: # 25483829  Wang, F. et al. 2015. Oncol. Rep. 33: 675-84.

PMID: # 25633838  Geng, J. et al. 2015. Cancer letters. 359: 275-87.

PMID: # 26149501  Le, OT. et al. 2015. Biochimica et biophysica acta. 1853: 2432-43.

PMID: # 26133373  Avey, D. et al. 2015. PLoS pathogens. 11: e1004993.

PMID: # 26324774  Kim, KS. et al. 2015. Journal of immunology (Baltimore, Md. : 1950). 195: 3345-54.

PMID: # 24057571  Fujiki, K. et al. 2014. Arch. Toxicol. 88: 403-14.

Citations 1 to 10 of 15 total
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