Mitoxantrone A type II topoisomerase inhibitor

Mitoxantrone (CAS 65271-80-9)

Mitoxantrone | CAS 65271-80-9 is rated 5.0 out of 5 by 1.
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Synonym: Novantrone; Dihydroxyanthraquinone
Application: A type II topoisomerase inhibitor
CAS Number: 65271-80-9
Purity: ≥97%
Molecular Weight: 444.48
Molecular Formula: C22H28N4O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mitoxantrone is a DNA intercalating drug that inhibits DNA synthesis and is used as an anti-cancer agent. Mitoxantrone is an inhibitor of Topo II.


References

McDonald, M., et al.: Drugs Exp. Clin. Res., 10, 745 (1984), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 17, 221 (1988),

Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), DMSO (89 mg/ml at 25° C), methanol (slightly), and ethanol (<1 mg/ml at 25° C). Insoluble in chloroform.
Storage :
Store at -20° C
Melting Point :
170-174° C
Boiling Point :
~805.7° C at 760 mmHg (Predicted)
Density :
1.45 g/cm3
Refractive Index :
n20D 1.71
IC50 :
L1210: IC50 = 0.04 nM (mouse); MDA-MB-435: IC50 = 0.35 nM (human); A2780: IC50 = 0.55 nM (human); HIV-1 integrase: IC50 = 3.8 µM; Topoisomerase II: IC50 = 5.3 µM
Ki Data :
mAChR M2: Ki= 77.9 nM (human); mAChR M4: Ki= 89.8 nM (human); mAChR M1: Ki= 0.18 µM (human); SR-2C: Ki= 1.87 µM (human); HERG: Ki= 2.94 µM (human)
pK Values :
pKa: 7.08 (Predicted), pKb: 9.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CB5748500
PubChem CID :
4212
Merck Index :
14: 6217
MDL Number :
MFCD00242942
Beilstein Registry :
2795126
SMILES :
C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO

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Certificate of Analysis

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Mitoxantrone  Product Citations

See how others have used Mitoxantrone. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26896646  Prado, S. et al. 2016. Biochem. Pharmacol. 107: 14-28.

PMID: # 23305710  Bankstahl, JP. et al. 2013. Drug Metab. Dispos. 41: 754-62.

PMID: # 23298861  Yasuda, K. et al. 2013. Drug Metab. Dispos. 41: 923-31.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Tila D; et al Tila D; et al. (PubMed ID: 26417350) determined that Mitoxantrone nisosomes showed higher toxicity in OVCAR-3 and MCF-7 cells than in HUVEC cells. -SCBT Publication Review
Date published: 2015-04-17
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