Minocycline, Hydrochloride A broad-spectrum tetracycline antibiotic that also acts as PARP inhibitor

Minocycline, Hydrochloride (CAS 13614-98-7)

Minocycline, Hydrochloride | CAS 13614-98-7 is rated 5.0 out of 5 by 1.
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Application: A broad-spectrum tetracycline antibiotic that also acts as PARP inhibitor
CAS Number: 13614-98-7
Purity: ≥98%
Molecular Weight: 493.9
Molecular Formula: C23H27N3O7•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Minocycline hydrochloride, also known as Minocycline, is a tetracycline compound with anticollagenase, antimicrobial, and anti-inflammatory properties. The compound has been reported to inhibit the enzymatic activity of PARP-1 (poly(ADP-ribose) polymerase-1) and angiogenesis. Studies show that doxycycline is an analog of minocycline and that both act as metalloprotease inhibitors. In addition, Minocycline is suggested to down-regulate CD40L on T cells and inhibit the replication of SIV and HIV. Minocycline hydrochloride is an inhibitor of MMP-3.


References

1. Tamargo, R.J., et al. 1991. Cancer Res. 51: 672-675. PMID: 1702361
2. Gilbertson-Beadling, S., et al. 1995. Cancer Chemother. Pharmacol. 36: 418-424. PMID: 7543375
3. Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102: 635-641. PMID: 8536384
4. Parangi, S., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 2002-2007. PMID: 8700875
5. Giuliani, F., et al. 2005. J. Leukoc. Biol. 78: 135-143. PMID: 15817702
6. Zink, M.C., et al. 2005. JAMA. 293: 2003-2011. PMID: 15855434
7. Tao, R., et al. 2010. J. Cardiovasc. Pharmacol. [Epub ahead of print]. PMID: 20881608

Physical State :
Solid
Solubility :
Soluble in DMSO (7 mg/ml), water (50 mg/ml), methanol, and aqueous solutions of alkali hydroxides and carbonates.
Storage :
Store at 4° C
Melting Point :
193-226° C
Refractive Index :
n20D ~1.72 (Predicted)
Optical Activity :
α20D -175°, c = 0.5 in 0.1ml/L HCl
IC50 :
Plasmodium falciparum W2: IC50 = 794.33 nM
pK Values :
pKa: 4.5 (Predicted), pKb: 11.06 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QI7630500
PubChem CID :
5281093
Merck Index :
14: 6202
MDL Number :
MFCD00083669
EC Number :
237-099-7
Beilstein Registry :
4836328
SMILES :
CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=O)/C(=C(/N)\\O)/C1=O)O)O)O)N(C)C.Cl

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Certificate of Analysis

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Minocycline, Hydrochloride  Product Citations

See how others have used Minocycline, Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28369077  Vandooren, J. et al. 2017. PLoS ONE. 12: e0174853.

PMID: # 9777589  Vanheusden, A. et al. 1998. J. Periodont. Res. 33: 377-385.

PMID: # 7774340  Light, RW. et al. 1994. Chest. 106: 577-582.

PMID: # 8514472  Ohkawa, M. et al. 1993. Int Urol Nephrol. 25: 37-43.

PMID: # 7447416  Sanders, WJ. et al. 1980. Antimicrob. Agents Chemother. 18: 529-531.

PMID: # 705904  Torres, JR. et al. 1978. Tubercle. 59: 193-195.

Citations 1 to 6 of 6 total

How it should be stored after dissolving?

Asked by: Esclerosis 520
Thank you for your message. Please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-27

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Minocycline, Hydrochloride, sc-203339, is in yellow powder form.
Answered by: Chemical Support 4
Date published: 2017-04-25
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Rated 5 out of 5 by from Light Light, RW. et al. (PubMed 7774340) tested Minocycline, hydrochloride, a broad spectrum tetracycline antibiotic, to determine its efficacy as a sclersoing agent to produce pleurodesis in rabbit models. Minocycline was tested against tetracycline, a known and effective sclersoing agent, and found to induce pleurodesis at a dosage that was five times lower than that of tetracycline. -SCBT Publication Review
Date published: 2015-03-26
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