Mitefosine, a PI 3-kinase and Akt inhibitor belonging to the alkylphosphocholines, has also been shown to inhibit anti-IgE induced histamine release from skin mast cells. Experimental studies show that this agent can reduce cytokines IL-1β, IL-4, and IL-6 in certain skin tissue cells and also strongly impede the esterification of cholesterol. Additionally, Miltefosine displays the ability to methylate CDP-choline (sc-200713) and phosphatidylethanolamine which interferes with biosynthesis of phosphatidylcholine. Furthermore, data suggests that this compound can slow down the formation of sphingomyelin, which promotes intracellular accumulation of ceramide. Miltefosine is an inhibitor of CCT and PKC.
1. Chugh, P., et al. 2008. Retrovirology. 5: 11. PMID: 18237430 2. Bäumer, W., et al. 2010. Eur. J. Pharmacol. 628: 226-232. PMID: 19917276 3. Jiménez-López, J.M., et al. 2010. Lipids Health Dis. 9: 33. PMID: 20338039
Soluble in water (10 mg/ml), DMSO (800 µg/ml), ethanol (1 mg/ml), PBS(pH7.2) (2.5 mg/ml), and DMF (~50 µg/ml).
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
CheshenkoCheshenko, N. et al. (PubMed 23507869) used Miltefosine, a PI3K/Akt inhibitor, to determine if Akt signaling contributes to herpes simplex virus (HSV) cell entry. Inhibition of Akt signaling by Miltefosine caused inhibited HSV-induced calcium release, viral entry, and plaque formation. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.