MG-132 [Z-Leu-Leu-Leu-CHO]A proteasome and NF-κB inhibitor

MG-132 [Z-Leu-Leu-Leu-CHO] (CAS 133407-82-6)

MG-132 [Z-Leu-Leu-Leu-CHO] | CAS 133407-82-6 is rated 5.0 out of 5 by 2.
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Synonym: (S)-MG132; Z-LLL-al; Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
Application: A proteasome and NF-κB inhibitor
CAS Number: 133407-82-6
Purity: >98%
Molecular Weight: 475.62
Molecular Formula: C26H41N3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

MG-132 [Z-Leu-Leu-Leu-CHO] is a potent, reversible, and cell-permeable proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. For instance, MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. Also, MG-132 has been shown to prevent beta-secretase cleavage of amyloid precursor protein (APP). Additionally, MG-132 is an inhibitor of 26S Proteasome and calpain, as well as, an activator of JNK1, c-Jun and c-Fos.

Related products include sc-351846 (sc-351846).


References

1. Lee, D.H. and Goldberg, A.L. 1998. Trends Cell Biol. 8: 397-403. PMID: 9789328

2. Arlt, A., et al. 2001. Oncogene. 20: 859-868. PMID: 11314019

3. Steinhilb, M. L., et al. 2001. J Biol Chem. 276(6):4476-4484. PMID: 11084038

4. Elliott, P.J., et al. 2003. J. Mol. Med. 81: 235-245. PMID: 12700891

5. Vivier, M., et al. 2008. J. Med. Chem. 51: 1043-1047. PMID: 18237109

6. Ye, X. et al. 2014. PLoS Pathog. 10(4): e1004070. PMID: 24722419

Physical State :
Solid
Sequence :
Z-Leu-Leu-Leu-CHO
Solubility :
Soluble in ethanol (100 mM), and DMSO (100 mM).
Storage :
Store at -20° C
Optical Activity :
α20D -65.5°, c = 1 in chloroform
IC50 :
NF-κB activation: IC50 = 3 µM; Suc-LLVY-AMC cleaving activity of proteasome: IC50 = 0.85 µM; Z-LLL-AMC cleaving activity of proteasome: IC50 = 0.1 µM; calpain: IC50 = 1.2 µM; IκBα degradation: IC50 = 3 µM
Ki Data :
proteasome: Ki= 4 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
OH2824610
PubChem CID :
462382
MDL Number :
MFCD00674886
SMILES :
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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MG-132 [Z-Leu-Leu-Leu-CHO]  Product Citations

See how others have used MG-132 [Z-Leu-Leu-Leu-CHO]. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 79 total

PMID: # 31078367  Joa, H. et al. 2019. Phytomedicine. 152938.

PMID: # 31086178  Dabral, S. et al. 2019. Nat Commun. 10: 2130.

PMID: # 30849304  Rosas, MG. et al. 2019. Biochem. Pharmacol. 163: 362-370.

PMID: # 30821592  Peng, M.|Wang, J.|Tian, Z.|Zhang, D.|Jin, H.|Liu, C.|Xu, J.|Li, J.|Hua, X.|Xu, J.|Huang, C.|Huang, C.| et al. 2019. Autophagy.

PMID: # 31052354  Yang, IH. et al. 2019. Molecules. 24:

PMID: # 31222373  Luo, Y. et al. 2019. Cell. Mol. Life Sci.

PMID: # 29467492  Di Costanzo, A. et al. 2018. Oncogene. 37: 2559-2572.

PMID: # 29321329  St Gelais, C. et al. 2018. J. Virol. 92:

PMID: # 29884303  Ullah, R. et al. 2018. Placenta. 66: 57-64.

PMID: # 30275345  Fan, W. et al. 2018. Mol. Cell. Biol.

Citations 1 to 10 of 79 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. MG-132 [Z-Leu-Leu-Leu-CHO], sc-201270, is a crystalline solid.
Answered by: Chemical Support 4
Date published: 2017-03-15
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Rated 5 out of 5 by from Good quality Good quality, worked well in cell culture studies.
Date published: 2015-10-16
Rated 5 out of 5 by from Ye Ye, X. et al. (PubMed 24722419) used MG-132 [Z-Leu-Leu-Leu-CHO], a potent, reversible and selective proteasome inhibitor, to confirm the involvement of ubiquitin-proteasome pathway in miR-21 mediated desmin degradation. MG-132 eliminated the effect of miR-21 on desmin downregulation, indicating that miR-21 promotes desmin degradation through the ubiquitin-proteasome pathway. -SCBT Publication Review
Date published: 2015-06-18
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