MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. It is also an an inhibitor of calpain. MG-132 [Z-Leu-Leu-Leu-CHO] is an inhibitor of 26S Proteasome and an activator of JNK1, c-Jun and c-Fos.
1. Lee, D.H. and Goldberg, A.L. 1998. Trends Cell Biol. 8: 397-403. PMID: 9789328
2. Arlt, A., et al. 2001. Oncogene. 20: 859-868. PMID: 11314019
3. Elliott, P.J., et al. 2003. J. Mol. Med. 81: 235-245. PMID: 12700891
4. Vivier, M., et al. 2008. J. Med. Chem. 51: 1043-1047. PMID: 18237109
5. Ye, X. et al. 2014. PLoS Pathog. 10(4): e1004070. PMID: 24722419
See how others have used MG-132 [Z-Leu-Leu-Leu-CHO]. Click on the entry to view the PubMed entry .
PMID: # 27151455
Kim, SJ. et al. 2016. Activated Rac1 regulates the degradation of IκBα and the nuclear translocation of STAT3-NFκB complexes in starved cancer cells. Exp. Mol. Med.. 48: e231.
PMID: # 26728942
Guo, Z. et al. 2016. DCAF1 controls T-cell function via p53-dependent and -independent mechanisms. Nat Commun. 7: 10307.
PMID: # 25622294
Silva, GM. et al. 2015. K63 polyubiquitination is a new modulator of the oxidative stress response. Nat. Struct. Mol. Biol.. 22: 116-23.
PMID: # 26554417
Zhuang, T. et al. 2015. p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells. Oncotarget. 6: 43853-68.
PMID: # 25996284
Sieprath, T. et al. 2015. Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates. Nucleus (Austin, Tex.). 6: 236-46.
PMID: # 26231201
Liu, Y. et al. 2015. A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function. FASEB J.. 29: 4829-39.
PMID: # 25691063
Jha, H.C. et al. 2015. EBNA3C regulates p53 through induction of Aurora kinase B. Oncotarget. 6: 5788-803.
PMID: # 26183205
Liu, Y. et al. 2015. Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition. FEBS Lett.. 589: 2233-40.
PMID: # 25500897
Fiebiger, BM. et al. 2015. Polyubiquitination of lysine-48 is an essential but indirect signal for MHC class I antigen processing. European journal of immunology. 45: 716-27.
PMID: # 25043125
Yu, HJ. et al. 2015. Inhibition of myeloid cell leukemia-1: Association with sorafenib-induced apoptosis in human mucoepidermoid carcinoma cells and tumor xenograft. Head Neck. 37: 1326-35.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2017 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.