Metronidazole An antibiotic affective against protozoa and anaerobic gram-positive and gram-negative bacteria

Metronidazole (CAS 443-48-1)

Metronidazole | CAS 443-48-1 is rated 4.0 out of 5 by 1.
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Synonym: Metronidazol; Trichopol; Vagilen; Clont; 2-Methyl-5-nitroimidazole-1-ethanol
Application: An antibiotic affective against protozoa and anaerobic gram-positive and gram-negative bacteria
CAS Number: 443-48-1
Purity: ≥99%
Molecular Weight: 171.15
Molecular Formula: C6H9N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Metronidazole is a limited spectrum antibiotic that actively deters the growth of protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria. The first use of this antibiotic was to suppress protozoans such as Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Further studies show that Metronidazole has been used to repress the growth of gram-negative anaerobes belonging to the Bacteroides and Fusobacterium, and gram-positive anaerobes such as peptostreptococcus and Clostridia. The advantages of this antibiotic is that it affects a high percentage of gram-negative bacteria and has greater tissue penetration. Furthermore, the gene hefA codes for the TolC efflux pump in Helicobacter pylori which is resistant to Metronidazole.


References

1. Freeman, C.D., et al. 1997. Drugs. 54: 679-708. PMID: 9360057
2. Tsugawa, H., et al. 2010. Biochem Biophys Res Commun. [Epub ahead of print]. PMID: 21147064

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml at 20° C), ethanol (5 mg/ml), methanol, chloroform (<0.5 mg/ml), and DMSO (34 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
159-161° C (lit.)
Boiling Point :
~405.4° C at 760 mmHg (Predicted)
Density :
~0.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Trichomonas vaginalis: IC50 = 0.21 µM; Entamoeba histolytica: IC50 = 0.35 µM; Giardia intestinalis: IC50 = 0.1 µg/ml; HeLa: IC50 = >1000 µg/ml (human)
pK Values :
pKa: 2.38, pKb: 2.58 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NI5600000
PubChem CID :
4173
Merck Index :
14: 6157
MDL Number :
MFCD00009750
EC Number :
207-136-1
Beilstein Registry :
611683
SMILES :
CC1=NC=C(N1CCO)[N+](=O)[O-]

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Certificate of Analysis

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Metronidazole  Product Citations

See how others have used Metronidazole. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28554545  Stjern, L. et al. 2017. International journal of pharmaceutics. 531: 595-605.

Citations 1 to 1 of 1 total

Why there is no Metronidazole as oral solution?

Asked by: Steve314
Thank you for your question. Our products are produced and sold exclusively for research purposes and are not specified for use as therapeutics.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29

Can the metronidazole powder be heated (as part of the water phase while making a cream) or does it lose its efficacy if exposed to heat?

Asked by: RafaNora
Thank you for your question. This chemical, Metronidazole: sc-204805, is intended for research use only and is not intended for Therapeutic or Diagnostic use. It is soluble in water (10 mg/ml at 20C), ethanol (5 mg/ml), methanol, chloroform (&lt;0.5 mg/ml), and DMSO (34 mg/ml at 25C).
Answered by: Technical Support
Date published: 2018-11-11

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-204805, is provided as a white to yellowish crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-23

What is the stability of this compound after reconstituting in water?

Asked by: two2igm05
Thank you for your question. Metronidazole, sc-204805, once dissolved should be stored at -80&deg; C and consumed as soon as possible.
Answered by: TechService7
Date published: 2016-12-28

Hello, what is the half-life of Metronidazole in its powder form when kept at 4C? Thank you

Asked by: l2323
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Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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