Methyl-L-NIO HydrochlorideA competitive NOS inhibitor

Methyl-L-NIO Hydrochloride (CAS 150403-96-6)

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Synonym: N5-(1-iminopropyl)-L-ornithine, monohydrochloride
Application: A competitive NOS inhibitor
CAS Number: 150403-96-6
Molecular Weight: 223.70
Molecular Formula: C8H17N3O2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Methyl-L-NIO (hydrochloride) is a competitive NOS inhibitor that competes with L-arginine for the amino acid binding site. Methyl-L-NIO (hydrochloride) is a more potent inhibitor of NOS1 (nNOS) (Ki = 3.0 μM) than NOS3 (eNOS) (Ki = 10.0 μM) or NOS2 (iNOS) (Ki = 9.5 μM).


References

1. Babu, B R., et al., 1998. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. The Journal of biological chemistry. 273(15): 8882-9. PMID: 9535869

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
90470185
SMILES :
CCC(=NCCC[C@@H](C(=O)O)N)N.Cl

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Certificate of Analysis

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