Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
1. Kim, H., et al., 2001. Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. Molecular pharmacology. 60(5): 972-80. PMID: 11641425
See how others have used Methimazole. Click on the entry to view the PubMed entry .
PMID: # 27611926 Özgür, E. et al. 2016. J Clin Res Pediatr Endocrinol. 8: 439-444.
PMID: # 25758293 Kocaturk, T. et al. 2016. Cutan Ocul Toxicol. 35: 36-40.
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