Methimazole A JAK/STAT signaling pathway inhibitor

Methimazole (CAS 60-56-0)

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Synonym: Favistan; Mercazolyl; Strumazol
Application: A JAK/STAT signaling pathway inhibitor
CAS Number: 60-56-0
Purity: ≥98%
Molecular Weight: 114.17
Molecular Formula: C4H6N2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.


References

1. Kim, H., et al., 2001. Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. Molecular pharmacology. 60(5): 972-80. PMID: 11641425

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (23 mg/ml at 25° C), ethanol (23 mg/ml at 25° C), chloroform (~222.22 mg/ml), water (~200 mg/ml), and methanol.
Storage :
Store at room temperature
Melting Point :
144-147° C (lit.)
Boiling Point :
280° C (dec.)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
LPO: IC50 = 11.8 µM (human); CYP51A1: IC50 >200 µM (human); Dopamine beta-hydroxylase: IC50 = 754 µM (bovine)
Ki Data :
Dopamine beta-hydroxylase: Ki= 45 µM (bovine)
pK Values :
pKa: 12.37 (Predicted), pKb: -3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NI8615000
PubChem CID :
1349907
Merck Index :
14: 5971
MDL Number :
MFCD00179321
EC Number :
200-482-4
Beilstein Registry :
108646
SMILES :
CN1C=CN=C1S

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Certificate of Analysis

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Methimazole  Product Citations

See how others have used Methimazole. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27611926  Özgür, E. et al. 2016. J Clin Res Pediatr Endocrinol. 8: 439-444.

PMID: # 25758293  Kocaturk, T. et al. 2016. Cutan Ocul Toxicol. 35: 36-40.

Citations 1 to 2 of 2 total
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