MES solution Used as a running buffer for resolving very small proteins

MES solution (CAS 4432-31-9)

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Synonym: 2-(N-Morpholino)ethanesulfonic acid
Application: Used as a running buffer for resolving very small proteins
CAS Number: 4432-31-9
Molecular Weight: 195.24
Molecular Formula: C6H13NO4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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MES solution [2-(N-Morpholino) ethanesulfonic Acid] has a pKa value near physiological pH, it is not absorbed through cell membranes, and it is essentially transparent to UV light. It is primarily used as a running buffer for resolving very small proteins (ex: 13 kDa) on bis-tris gels. Also used in cation-exchange chromatography and as a biological buffer in plant cell cultures. MES solutions can be prepared to the desired pH by titrating the free acid with sodium hydroxide.

Also available: MES hydrate (sc-216094); MES, Sodium Salt (sc-216095); MES hemisodium salt (sc-216093)


References

1. Good, N.E., et al. 1966. Biochemistry. 5: 467-477. PMID: 5942950
2. Graf, H., et al. 1994. Bioseparation. 4: 7-20. PMID: 7764588
3. Anfossi, L., et al. 2003. Ann Chim. 93: 499-512. PMID: 12911143
4. Mönch, S., et al. 2010. Anal. Biochem. 398: 150-160. PMID: 19903444
5. Teste, B., et al. 2010. Talanta. 81: 1703-1710. PMID: 20441961

Formulation :
0.5 M in H2O
Physical State :
Liquid
Solubility :
Soluble in water (miscible).
pH :
2.5-4.0 (25° C in neat)
Refractive Index :
n20D 1.52 (Predicted)
pK Values :
pKa: 0.87 (Predicted), pKb: 7.50 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
78165
Merck Index :
14: 5902
MDL Number :
MFCD00006181
EC Number :
224-632-3
Beilstein Registry :
6350956
SMILES :
C1COCCN1CCS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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