Meropenem with sodium carbonate is a salt form of Meropenem, a β-lactam antibiotic of the carbapenem subclass that has been shown to inhibit penicillinase-negative, -positive and methicillin-susceptible staphylococci. This compound demonstrates the ability to also affect strains of 11 species of streptococci. Mechanistic studies suggest that Meropenem's antimicrobial activity is based on its high affinity for the majority of penicillin-binding proteins, which are cell wall-synthesizing enzymes. Meropenem is very effective because it resists inactivation by the majority of microbial LACTB (β-lactamases) as well as kidney dehydropeptidase I. Experiments have shown Meropenem to have a low toxicity profile and, in contrast to similar compounds, no central nervous system toxicity.
1. Honorato, J., et al., 1997. [Clinical pharmacology and indications of meropenem in severe pediatric infection]. Enfermedades infecciosas y microbiología clínica. 15 Suppl 1(): 38-44. PMID: 9410068
2. Cottagnoud, P., et al., 2002. Cellular and molecular aspects of drugs of the future: meropenem. Cellular and molecular life sciences : CMLS. 59(11): 1928-33. PMID: 12530523
3. Nicolau, David P., et al., 2008. Pharmacokinetic and pharmacodynamic properties of meropenem. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 47 Suppl 1(): S32-40. PMID: 18713048
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