Meropenem is a β-lactam antibiotic of the carbapenem subclass that has been shown to inhibit penicillinase-negative, -positive and methicillin-susceptible staphylococci. This compound demonstrates the ability to also affect strains of 11 species of streptococci. Mechanistic studies suggest that Meropenem's antimicrobial activity is based on its high affinity for the majority of penicillin-binding proteins, which are cell wall-synthesizing enzymes. Meropenem is very effective because it resists inactivation by the majority of microbial LACTB (β-lactamases) as well as kidney dehydropeptidase I. Experiments have shown Meropenem to have a low toxicity profile and, in contrast to similar compounds, no central nervous system toxicity.
1. Kayser, F H., et al., 1989. Activity of meropenem, against gram-positive bacteria. The Journal of antimicrobial chemotherapy. 24 Suppl A(): 101-12. PMID: 2808202 2. Honorato, J., et al., 1997. [Clinical pharmacology and indications of meropenem in severe pediatric infection]. Enfermedades infecciosas y microbiología clínica. 15 Suppl 1(): 38-44. PMID: 9410068 3. Cottagnoud, P., et al., 2002. Cellular and molecular aspects of drugs of the future: meropenem. Cellular and molecular life sciences : CMLS. 59(11): 1928-33. PMID: 12530523 4. Nicolau, David P., et al., 2008. Pharmacokinetic and pharmacodynamic properties of meropenem. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 47 Suppl 1(): S32-40. PMID: 18713048
Soluble in water (8 mg/ml at 25° C), 5% monobasic potassium phosphate solution, ethanol (<1 mg/ml at 25° C), and DMSO (77 mg/ml at 25° C).
Store at 4° C
325.85° C (Predicted)
~627.4° C at 760 mmHg (Predicted)
~1.4 g/cm3 (Predicted)
n20D 1.64 (Predicted)
α20/D -19°±2°, c = 0.44 in water
Displacement of [14C]benzylpenicillin : IC50 = 3.3 ng/ml (Pseudomonas aeruginosa ATCC 15692); Binding of bocillin FL to PBP4 : IC50 = 8 ng/ml (Pseudomonas aeruginosa PAO1 membranes); Binding of bocillin FL to PBP2 : IC50 = 8 ng/ml (Escherichia coli MC4100 membranes)
pKa: 4.27 (Predicted), pKb: 8.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Thank you for your question. The water content for sc-205746 is 12.59%. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing email@example.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-11
What is the physical appearance of this compound?
Asked by: two2igm05
Thank you for your question.
Meropenem, sc-205746, is a light yellow crystalline powder.
Rated 5 out of
SuekeSueke, H. et al. (PubMed 26325409) investigated the pharmacokinetics of Meropenem for sse in bacterial keratitis. Found that Meropenem has very low toxicity in vitro. It has good corneal penetration, achieving anterior chamber concentrations above MIC90 for bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, streptococci, coagulase-negative staphylococci, and the Enterobacteriaceae. -SCBT Publication Review
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