MEN10376 A neurokinin 2 (NK2) receptor antagonist

MEN10376 (CAS 135306-85-3)

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Synonym: H-ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2
Application: A neurokinin 2 (NK2) receptor antagonist
CAS Number: 135306-85-3
Purity: 97%
Molecular Weight: 1081.3
Molecular Formula: C57H68N12O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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MEN10376 is a NK-2R (Tachykinin (neurokinin 2), NK2 receptor) antagonist that is used in a variety of neurokinin receptors studies. NK2 receptors mediate contractile effects in the human small intestine and colon circular muscle strips. Studies show that activation of NK2 increases that excitability of capsaicin-responsive (C-R) phasic afferent neurons.


References

1. Dougherty, P.M., et al. 1994. J. Neurophysiol. 72: 1464-1475. PMID: 7823080
2. Lecci, A., et al. 2006. Auton Neurosci. 126-127: 232-249. PMID: 16616700
3. Sculptoreanu, A., et al. 2007. Exp. Neurol. 205: 92-100. PMID: 17362934
4. Paterson, W.G., et al. 2007. Gut. 56: 1347-1352. PMID: 17525090
5. Sculptoreanu, A., et al. 2009. Exp. Neurol. 219: 562-573. PMID: 19631644

Physical State :
Solid
Sequence :
Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2
Solubility :
Soluble in water (partly miscible), and acetic acid.
Storage :
Store at -20° C
Boiling Point :
~1555.4° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.67
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
124003
MDL Number :
MFCD00144736
SMILES :
CC(C)[C@@H](C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CC=C(C=C7)O)NC(=O)[C@H](CC(=O)O)N

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Certificate of Analysis

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MEN10376  Product Citations

See how others have used MEN10376. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 17362934  Sculptoreanu, A. et al. 2007. Exp. Neurol. 205: 92-100.

Citations 1 to 1 of 1 total
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