Melittin An apoptosis inducer, NF-κB inhibitor, and PLA2 activator

Melittin (CAS 37231-28-0)

Melittin | CAS 37231-28-0 is rated 5.0 out of 5 by 1.
  • y_2019, m_4, d_21, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200868, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 88ms
  • REVIEWS, PRODUCT
Synonym: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
Application: An apoptosis inducer, NF-κB inhibitor, and PLA2 activator
CAS Number: 37231-28-0
Purity: ≥97%
Molecular Weight: 2846.45
Molecular Formula: C131H229N39O31
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Melittin, an antibacterial originally derived from Apis mellifera, has been reported to cause apoptosis via induction of reactive oxygen species production in cells. Additionally, this compound has been found to suppress 4α-Phorbol 12-myristate 13-acetate (sc-202021) induced invasion of proliferative cells via inhibition of activator protein-1 and NF-κB. Other experiments show Melittin to be able to also suppress PMA-induced phosphorylation of ERK and JNK mitogen-activated protein kinases. This compound also activates phospholipase A2 (PLA2).


References

1. Han, S., et al. 2009. J Asian Nat Prod Res. 11: 796-804. PMID: 20183327
2. Park, C., et al. 2010. Biochem. Biophys. Res. Commun. 394: 170-172. PMID: 20188067
3. Park, J.H., et al. 2010. Mol. Cells. 29: 209-215. PMID: 20082219

Appearance :
Powder
Physical State :
Solid
Derived From :
Synthetic
Sequence :
Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Solubility :
Soluble in water, and 20% acetonitrile (1 mg/ml).
Storage :
Store at -20° C
Ki Data :
Protein kinase C: Ki= 5-7 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
OS3960000
Transport :
UN 3462, Class 6.1, Packing group I
PubChem CID :
16133648
Merck Index :
14: 5824
MDL Number :
MFCD00076868
EC Number :
253-417-7
SMILES :
CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N)NC(=O)CN

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Melittin  Product Citations

See how others have used Melittin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25755832  Wang, X. et al. 2015. Am J Transl Res. 7: 100-10.

Citations 1 to 1 of 1 total

Dear Responsible, Just I wanted to ask if the Melittin (CAS 37231-28-0) is obtained from synthesis of from bee venom (by extortion). Thanks in advance Mario

Asked by: Mseki
Thank you very much for your question. The sc-200868 is derived from chemycal synthesis with the sequence Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2. Please contact our Technical Service by phone or email or by Live Chat if you have any further questions.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-30
  • y_2019, m_4, d_21, h_6CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_200868, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 111ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Choi JH; et al Choi JH; et al. (PubMed ID: 26330195) determined that Melittin, the main component in bee venom, could be a promising antimicrobial agent for therapy of MRSA induced wounds. -SCBT Publication Review
Date published: 2015-07-16
  • y_2019, m_4, d_21, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200868, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 34ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.