Meclocycline A close structural analogue of methacycline which shows antibacterial and antiprotozoan activity

Meclocycline (CAS 2013-58-3)

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Synonym: Meclociclina; Meclocyclinum
Application: A close structural analogue of methacycline which shows antibacterial and antiprotozoan activity
CAS Number: 2013-58-3
Molecular Weight: 476.86
Molecular Formula: C22H21ClN2O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Meclocycline is a semi-synthetic tetracycline prepared by dehydration of the 6-hydroxy group of chlortetracycline to yield an exocyclic 6-methylene. Meclocyline is a close structural analogue of methacycline. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Physical State :
Solid
Derived From :
Semi-synthetic
Solubility :
Soluble in ethanol, methanol, DMF, DMSO. Limited water solubility.
Storage :
Store at -20° C
Melting Point :
339.97° C (Predicted)
Boiling Point :
~837.0° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
pK Values :
pKa: 4.5 (Predicted), pKb: 10.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
QI7830000
PubChem CID :
54676539
MDL Number :
MFCD00864872
EC Number :
217-938-3
SMILES :
CN(C)[C@H]1[C@@H]2[C@H]([C@@H]3C(=C)C4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O

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Certificate of Analysis

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