Mead Acid (20:3, n-9) is an unsaturated fatty acid which is a precursor in the biosynthesis of prostaglandins, thromboxanes and leukotrienes (the eicosanoids comprising the "arachidonic cascade"). This product can be converted to 3-series cysteinyl-leukotrienes but cannot serve as a COX substrate. The kidneys from essential fatty acid deficient rats are less immunogenic when transplanted, and the metabolites of eicosatrienoic acid are believed to play a role in altering the immune status of these organs. Research has shown that this compound has immunomodulatory and anti-inflammatory effects.
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3. Lefkowith, J.B. 1990. Adv. Prostaglandin Thromboxane Leukot. Res. 20: 224-231. PMID: 2144697
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