Mead Acid (20:3, n-9) A precursor in biosynthesis of prostaglandins, thromboxanes and leukotrienes - anti-inflammatory

Mead Acid (20:3, n-9) (CAS 20590-32-3)

Mead Acid (20:3, n-9) | CAS 20590-32-3 is rated 5.0 out of 5 by 1.
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Synonym: 5(Z),8(Z),11(Z)-Eicosatrienoic Acid; cis-5,8,11-Eicosatrienoic acid
Application: A precursor in biosynthesis of prostaglandins, thromboxanes and leukotrienes - anti-inflammatory
CAS Number: 20590-32-3
Purity: ≥95%
Molecular Weight: 306.48
Molecular Formula: C20H34O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Mead Acid (20:3, n-9) sc-200772 1 mg $79.00
Mead Acid (20:3, n-9) sc-200772A 10 mg $476.00

Mead Acid (20:3, n-9) is an unsaturated fatty acid which is a precursor in the biosynthesis of prostaglandins, thromboxanes and leukotrienes (the eicosanoids comprising the "arachidonic cascade"). This product can be converted to 3-series cysteinyl-leukotrienes but cannot serve as a COX substrate. The kidneys from essential fatty acid deficient rats are less immunogenic when transplanted, and the metabolites of eicosatrienoic acid are believed to play a role in altering the immune status of these organs. Research has shown that this compound has immunomodulatory and anti-inflammatory effects.


References

1. Lefkowith, J.B., et al. 1986. Prostaglandins Leukot Med. 23: 123-127. PMID: 3020581
2. Schreiner, G.F., et al. 1988. Science. 240: 1032-1033. PMID: 3285468
3. Lefkowith, J.B. 1990. Adv. Prostaglandin Thromboxane Leukot. Res. 20: 224-231. PMID: 2144697

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol (10 mg/ml), acetone, ethyl acetate, methyl acetate, hexane, water (1.7 mg/ml) at 25° C, 0.1 M Na2CO3, DMSO, and DMF.
Storage :
Store at -20° C
Boiling Point :
78.0-80.0° C
Refractive Index :
n20D 1.49
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
5312531
MDL Number :
MFCD00065719
EC Number :
200-578-6
SMILES :
CCCCCCCC/C=C\C/C=C\C/C=C\CCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Kinoshita et al Kinoshita et al. (PubMed ID 25109488) found that mead acid inhibited the growth of KPL-1 human breast cancer cells by reducing VEGFR 1 and 2 expression. -SCBT Publication Review
Date published: 2015-05-28
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