MDL-28170 A cell permeable selective inhibitor of Calpain 1

MDL-28170 (CAS 88191-84-8)

MDL-28170 | CAS 88191-84-8 is rated 5.0 out of 5 by 1.
  • y_2018, m_12, d_14, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201301, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 71ms
  • REVIEWS, PRODUCT
Synonym: Calpain Inhibitor III
Application: A cell permeable selective inhibitor of Calpain 1
CAS Number: 88191-84-8
Purity: ≥95%
Molecular Weight: 382.45
Molecular Formula: C22H26N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

MDL-28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells. MDL-28170 also inhibits cathepsin B. Additionally, this compound has been shown to be able to cross the blood-brain barrier and inhibit brain cysteine protease activity, therefore potentially protecting against cortical neuronal damage. Also proven to prevent anoxia in murine optic nerves. MDL-28170 is an inhibitor of Gamma-secretase and Calpain 2.


References

1. Song, D.K., et al. 1994. J. Neurosci. Res. 39: 474-481. PMID: 7884824
2. Chard, P.S., et al. 1995. Neuroscience. 65: 1099-1108. PMID: 7617165
3. Li, P.A., et al. 1998. Neurosci. Lett. 247: 17-20. PMID: 9637399
4. Ray, S.K., et al. 2000. Brain Res. 852: 326-334. PMID: 10678759
5. Jiang, Q., et al. 2000. J. Neurochem. 74: 2101-2107. PMID: 10800955

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mM), and methanol. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
230.92° C
Boiling Point :
~595.6° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.55
IC50 :
Calpain 1: IC50 = 11 nM (human)
Ki Data :
Calpain I: Ki= 8 nM; Cathepsin B: Ki= 24 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11199915
MDL Number :
MFCD00798796
SMILES :
CC(C)[C@@H](C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

MDL-28170  Product Citations

See how others have used MDL-28170. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 26087461  Kharatmal, SB. et al. 2015. Neuropharmacology. 97: 113-21.

PMID: # 25108379  Shivanna, V. et al. 2014. Virology. 464-465: 287-95.

PMID: # 17317687  Guo, H. et al. 2007. J. Biochem. 141: 635-640.

PMID: # 15731107  Wilker, E.W. et al. 2005. J. Biol. Chem. 280: 18891-18898.

PMID: # 15740849  Korhonen, P. et al. 2005. Neurosci. Lett. 377: 121-124.

PMID: # 15777753  Kawamura, M. et al. 2005. Brain Res. 1037: 59-69.

PMID: # 15731107  Wilker, EW. et al. 2005. J. Biol. Chem. 280: 18891-18898.

PMID: # 12764095  Crocker, SJ. et al. 2003. J. Neurosci. 23: 4081-4091.

PMID: # 9524069  Lee, HJ. et al. 1998. Biol. Chem. 379: 175-183.

PMID: # 9302348  Urthaler, F. et al. 1997. Cardiovasc. Res. 35: 60-67.

Citations 1 to 10 of 10 total

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, MDL-28170 (CAS 88191-84-8), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-04-07
  • y_2018, m_12, d_14, h_15CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_201301, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 81ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Used in our lab Used in our lab, no complaints, worked well.
Date published: 2015-06-29
  • y_2018, m_12, d_14, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201301, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 78ms
  • REVIEWS, PRODUCT
--%>

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.